A substantial and diverse body of literature suggests that the pathophysiology of
schizophrenia is related to deficits of bioenergetic function. While antipsychotics are an …

These results support that ketogenic diet may present a novel therapeutic approach through
restoring brain energy metabolism in schizophrenia. Randomized controlled clinical trials …

Innate immunity has been linked to initiation of Alzheimer's disease and multiple sclerosis.
Moreover, risk of first-episode psychosis (FEP) and schizophrenia (Sz) is increased after …

Background We recently reported increased levels of neutrophils, monocytes and C-reactive
protein (CRP) correlated with symptom severity in acute schizophrenia. Here, we …

Introduction Clozapine and olanzapine are some of the most effective antipsychotics, but
both are associated with weight gain and relevant metabolic disturbances, including pre …

Background Metabolic syndrome and impaired insulin sensitivity may occur as side effects
of atypical antipsychotic drugs. However, studies of peripheral insulin resistance using the …

Psychiatric disorders are complex, disabling, and chronic conditions that are often
accompanied by one or more systemic medical comorbidities. In this narrative review, we …

Recent transcriptomic, proteomic and metabolomics studies have highlighted an abnormal
cerebral glucose and energy metabolism as one of the potential pathophysiological …

Drug-naïve psychotic patients show metabolic and hepatic dysfunctions. The rat social
isolation model of psychosis allows to investigate mechanisms leading to these …

Schizophrenia and diabetes have been known to be linked disorders for decades. One
reason is due to the fact that a major side effect of antipsychotic medication treatment is …