Mechanisms and physiological implications of cooperative gating of clustered ion channels
Ion channels play a central role in the regulation of nearly every cellular process. Dating
back to the classic 1952 Hodgkin–Huxley model of the generation of the action potential, ion …
back to the classic 1952 Hodgkin–Huxley model of the generation of the action potential, ion …
Mechanisms of vascular smooth muscle contraction and the basis for pharmacologic treatment of smooth muscle disorders
FV Brozovich, CJ Nicholson, CV Degen, YZ Gao… - Pharmacological …, 2016 - ASPET
The smooth muscle cell directly drives the contraction of the vascular wall and hence
regulates the size of the blood vessel lumen. We review here the current understanding of …
regulates the size of the blood vessel lumen. We review here the current understanding of …
[HTML][HTML] Ion channels in the heart
Optimal cardiac function depends on proper timing of excitation and contraction in various
regions of the heart, as well as on appropriate heart rate. This is accomplished via …
regions of the heart, as well as on appropriate heart rate. This is accomplished via …
Ca2+ dynamics in interstitial cells: foundational mechanisms for the motor patterns in the gastrointestinal tract
The gastrointestinal (GI) tract displays multiple motor patterns that move nutrients and
wastes through the body. Smooth muscle cells (SMCs) provide the forces necessary for GI …
wastes through the body. Smooth muscle cells (SMCs) provide the forces necessary for GI …
Animal models to study cardiac arrhythmias
DJ Blackwell, J Schmeckpeper… - Circulation research, 2022 - Am Heart Assoc
Cardiac arrhythmias are a significant cause of morbidity and mortality worldwide, accounting
for 10% to 15% of all deaths. Although most arrhythmias are due to acquired heart disease …
for 10% to 15% of all deaths. Although most arrhythmias are due to acquired heart disease …
AKAP150-dependent cooperative TRPV4 channel gating is central to endothelium-dependent vasodilation and is disrupted in hypertension
Endothelial cell dysfunction, characterized by a diminished response to endothelial cell–
dependent vasodilators, is a hallmark of hypertension. TRPV4 channels play a major role in …
dependent vasodilators, is a hallmark of hypertension. TRPV4 channels play a major role in …
Murine electrophysiological models of cardiac arrhythmogenesis
CLH Huang - Physiological reviews, 2017 - journals.physiology.org
Cardiac arrhythmias can follow disruption of the normal cellular electrophysiological
processes underlying excitable activity and their tissue propagation as coherent wavefronts …
processes underlying excitable activity and their tissue propagation as coherent wavefronts …
Ser1928 phosphorylation by PKA stimulates the L-type Ca2+ channel CaV1.2 and vasoconstriction during acute hyperglycemia and diabetes
Hypercontractility of arterial myocytes and enhanced vascular tone during diabetes are, in
part, attributed to the effects of increased glucose (hyperglycemia) on L-type CaV1. 2 …
part, attributed to the effects of increased glucose (hyperglycemia) on L-type CaV1. 2 …
Graded Ca2+/calmodulin-dependent coupling of voltage-gated CaV1.2 channels
In the heart, reliable activation of Ca2+ release from the sarcoplasmic reticulum during the
plateau of the ventricular action potential requires synchronous opening of multiple CaV1. 2 …
plateau of the ventricular action potential requires synchronous opening of multiple CaV1. 2 …
Channelopathy pathogenesis in autism spectrum disorders
Autism spectrum disorder (ASD) is a syndrome that affects normal brain development and is
characterized by impaired social interaction as well as verbal and non-verbal …
characterized by impaired social interaction as well as verbal and non-verbal …