The Orexin/Hypocretin System, the Peptidergic Regulator of Vigilance, Orchestrates Adaptation to Stress
The orexin/hypocretin neuropeptide family has emerged as a focal point of neuroscientific
research following the discovery that this family plays a crucial role in a variety of …
research following the discovery that this family plays a crucial role in a variety of …
Anxiety and depression: what do we know of neuropeptides?
I Kupcova, L Danisovic, I Grgac, S Harsanyi - Behavioral Sciences, 2022 - mdpi.com
In modern society, there has been a rising trend of depression and anxiety. This trend
heavily impacts the population's mental health and thus contributes significantly to morbidity …
heavily impacts the population's mental health and thus contributes significantly to morbidity …
Lateral hypothalamus orexinergic projection to the medial prefrontal cortex modulates chronic stress-induced anhedonia but not anxiety and despair
D Liu, X Zheng, Y Hui, Y Xu, J Du, Z Du, Y Che… - Translational …, 2024 - nature.com
Chronic stress-induced anxiodepression is a common health problem, however its potential
neurocircuitry mechanism remains unclear. We used behavioral, patch-clamp …
neurocircuitry mechanism remains unclear. We used behavioral, patch-clamp …
Suvorexant, an FDA-approved dual orexin receptor antagonist, reduces oxycodone self-administration and conditioned reinstatement in male and female rats
JM Illenberger, FJ Flores-Ramirez, A Matzeu… - Frontiers in …, 2023 - frontiersin.org
Background: The Department of Health and Human Services reports that prescription pain
reliever (eg, oxycodone) misuse was initiated by 4,400 Americans each day in 2019. Amid …
reliever (eg, oxycodone) misuse was initiated by 4,400 Americans each day in 2019. Amid …
Hypocretin/orexin system in the nucleus accumbens as a promising player in the extinction and reinstatement of methamphetamine-induced CPP
H Amirteymori, S Karimi-Haghighi… - Progress in Neuro …, 2023 - Elsevier
One of the main obstacles in treating psychostimulant addiction is relapse even after long-
term abstinence. The nucleus accumbens (NAc) is located in the basal forebrain …
term abstinence. The nucleus accumbens (NAc) is located in the basal forebrain …
The role of orexin-1 receptors within the ventral tegmental area in the extinction and reinstatement of methamphetamine place preference
F Zamanirad, M Fattahi, H Amirteymori… - Behavioural Brain …, 2023 - Elsevier
Targeting the orexin system has recently been identified as one of the promising options for
treating drug addiction. It may be more feasible and achievable if we investigate the …
treating drug addiction. It may be more feasible and achievable if we investigate the …
Neuroinflammatory response in reward-associated psychostimulants and opioids: a review
S Karimi-Haghighi, S Chavoshinezhad… - Cellular and molecular …, 2023 - Springer
Substance abuse is one of the significant problems in social and public health worldwide.
Vast numbers of evidence illustrate that motivational and reinforcing impacts of addictive …
Vast numbers of evidence illustrate that motivational and reinforcing impacts of addictive …
The blockade of orexin receptors within the dentate gyrus of the hippocampus attenuated methamphetamine-induced reward learning during conditioning place …
S Modaberi, H Amirteymori, S Mesgar… - Pharmacology …, 2023 - Elsevier
Orexins and orexinergic receptors have been shown to play a critical role in reward
processing and drug addiction. Previous studies showed that the orexinergic system in the …
processing and drug addiction. Previous studies showed that the orexinergic system in the …
[HTML][HTML] Blockade of orexin receptor 1 attenuates morphine protracted abstinence-induced anxiety-like behaviors in male mice
H Ye, T Cao, Q Shu, Y Chen, Y Lu, Z He, Z Li - Psychoneuroendocrinology, 2023 - Elsevier
One negative emotional state from morphine protracted abstinence is anxiety which can
drive craving and relapse risk in opioid addicts. Although the orexinergic system has been …
drive craving and relapse risk in opioid addicts. Although the orexinergic system has been …
The role of orexin receptors within the CA1 area in the acquisition and expression of methamphetamine place preference
Abstract Treatment of Methamphetamine (METH) use disorder has become a crucial public
health issue. The orexin system manipulation has provided promising evidence to attenuate …
health issue. The orexin system manipulation has provided promising evidence to attenuate …