Tripartite motif containing-21 (TRIM21), an E3 ubiquitin ligase, was initially found to be
involved in antiviral responses and autoimmune diseases. Recently studies have reported …

Inhibiting the CDK2/cyclin A2 enzyme has been validated in multiple clinical manifestations
related to multiple types of cancer. Herein, novel series of pyrolo [2, 3-c] pyrazole, pyrolo [2 …

Simple Summary Pancreatobiliary cancers are a group of malignancies affecting the
pancreas and biliary tract and are among the cancers with the lowest survival rate. Current …

Cyclin-dependent kinase 2 (CDK2) is a promising target for cancer treatment, developing
new effective CDK2 inhibitors is of great significance in anticancer therapy. The involvement …

Ferroptosis, an iron‐dependent form of regulated cell death driven by excessive
accumulation of lipid peroxides, has become a promising strategy in cancer treatment …

Compared to most ATP-site kinase inhibitors, small molecules that target an allosteric pocket
have the potential for improved selectivity due to the often observed lower structural …

Background The faithful maintenance of DNA methylation homeostasis indispensably
requires DNA methyltransferase 1 (DNMT1) in cancer progression. We previously identified …

Although cyclin-dependent kinase 2 (CDK2) is a validated target for both cancer and
contraception, developing a CDK2 inhibitor with exquisite selectivity has been challenging …

Though palbociclib, a cyclin-dependent kinases 4 and 6 (CDK4/6) inhibitor has been
approved for treating breast cancer, two major clinical challenges remain:(i) Triple-negative …

Monkeypox virus (mpox virus) outbreak has rapidly spread to 82 non-endemic countries.
Although it primarily causes skin lesions, secondary complications and high mortality (1 …