Endoplasmic reticulum stress signals in the tumour and its microenvironment
X Chen, JR Cubillos-Ruiz - Nature Reviews Cancer, 2021 - nature.com
Protein handling, modification and folding in the endoplasmic reticulum (ER) are tightly
regulated processes that determine cell function, fate and survival. In several tumour types …
regulated processes that determine cell function, fate and survival. In several tumour types …
Tumor microenvironment signaling and therapeutics in cancer progression
Tumor development and metastasis are facilitated by the complex interactions between
cancer cells and their microenvironment, which comprises stromal cells and extracellular …
cancer cells and their microenvironment, which comprises stromal cells and extracellular …
The role of the unfolded protein response in cancer progression: From oncogenesis to chemoresistance
Tumour cells endure both oncogenic and environmental stresses during cancer
progression. Transformed cells must meet increased demands for protein and lipid …
progression. Transformed cells must meet increased demands for protein and lipid …
Unresolved endoplasmic reticulum stress engenders immune-resistant, latent pancreatic cancer metastases
A Pommier, N Anaparthy, N Memos, ZL Kelley… - Science, 2018 - science.org
INTRODUCTION Pancreatic ductal adenocarcinoma (PDA) is the fourth most common
cause of death from cancer worldwide and has a 5-year survival rate of 6%. Patients who …
cause of death from cancer worldwide and has a 5-year survival rate of 6%. Patients who …
M2 macrophage-derived exosomes suppress tumor intrinsic immunogenicity to confer immunotherapy resistance
N Zheng, T Wang, Q Luo, Y Liu, J Yang, Y Zhou… - …, 2023 - Taylor & Francis
ABSTRACT T-cell-based immune checkpoint blockade therapy (ICB) can be undermined by
local immunosuppressive M2-like tumor-associated macrophages (TAMs). However …
local immunosuppressive M2-like tumor-associated macrophages (TAMs). However …
Endoplasmic reticulum stress and atherosclerosis
GS Hotamisligil - Nature medicine, 2010 - nature.com
Atherosclerosis and related cardiovascular diseases represent one of the greatest threats to
human health worldwide. Despite important progress in prevention and treatment, these …
human health worldwide. Despite important progress in prevention and treatment, these …
Genetic studies provide clues on the pathogenesis of idiopathic pulmonary fibrosis
JA Kropski, WE Lawson, LR Young… - Disease models & …, 2013 - journals.biologists.com
Idiopathic pulmonary fibrosis (IPF) is a progressive and often fatal lung disease for which
there is no known treatment. Although the traditional paradigm of IPF pathogenesis …
there is no known treatment. Although the traditional paradigm of IPF pathogenesis …
[HTML][HTML] The unfolded protein response (UPR)-activated transcription factor X-box-binding protein 1 (XBP1) induces microRNA-346 expression that targets the human …
R Bartoszewski, JW Brewer, A Rab… - Journal of Biological …, 2011 - ASBMB
To identify endoplasmic reticulum (ER) stress-induced microRNAs (miRNA) that govern ER
protein influx during the adaptive phase of unfolded protein response, we performed miRNA …
protein influx during the adaptive phase of unfolded protein response, we performed miRNA …
[HTML][HTML] The role of the hypoxia-related unfolded protein response (UPR) in the tumor microenvironment
Simple Summary The complex signaling networks that different cancers utilize for cell
survival remain poorly understood. A major problem is the complexity of the tumor …
survival remain poorly understood. A major problem is the complexity of the tumor …
[HTML][HTML] Chemical chaperones reduce endoplasmic reticulum stress and prevent mutant HFE aggregate formation
SF de Almeida, G Picarote, JV Fleming… - Journal of Biological …, 2007 - ASBMB
HFE C282Y, the mutant protein associated with hereditary hemochromatosis (HH), fails to
acquire the correct conformation in the endoplasmic reticulum (ER) and is targeted for …
acquire the correct conformation in the endoplasmic reticulum (ER) and is targeted for …