Protein handling, modification and folding in the endoplasmic reticulum (ER) are tightly
regulated processes that determine cell function, fate and survival. In several tumour types …

Tumor development and metastasis are facilitated by the complex interactions between
cancer cells and their microenvironment, which comprises stromal cells and extracellular …

Tumour cells endure both oncogenic and environmental stresses during cancer
progression. Transformed cells must meet increased demands for protein and lipid …

INTRODUCTION Pancreatic ductal adenocarcinoma (PDA) is the fourth most common
cause of death from cancer worldwide and has a 5-year survival rate of 6%. Patients who …

ABSTRACT T-cell-based immune checkpoint blockade therapy (ICB) can be undermined by
local immunosuppressive M2-like tumor-associated macrophages (TAMs). However …

Atherosclerosis and related cardiovascular diseases represent one of the greatest threats to
human health worldwide. Despite important progress in prevention and treatment, these …

Idiopathic pulmonary fibrosis (IPF) is a progressive and often fatal lung disease for which
there is no known treatment. Although the traditional paradigm of IPF pathogenesis …

To identify endoplasmic reticulum (ER) stress-induced microRNAs (miRNA) that govern ER
protein influx during the adaptive phase of unfolded protein response, we performed miRNA …

Simple Summary The complex signaling networks that different cancers utilize for cell
survival remain poorly understood. A major problem is the complexity of the tumor …

HFE C282Y, the mutant protein associated with hereditary hemochromatosis (HH), fails to
acquire the correct conformation in the endoplasmic reticulum (ER) and is targeted for …