Cheating evolution: engineering gene drives to manipulate the fate of wild populations

J Champer, A Buchman, OS Akbari - Nature Reviews Genetics, 2016 - nature.com
Engineered gene drives—the process of stimulating the biased inheritance of specific genes—
have the potential to enable the spread of desirable genes throughout wild populations or to …

B chromosomes–a matter of chromosome drive

A Houben - Frontiers in plant science, 2017 - frontiersin.org
B chromosomes are supernumerary chromosomes which are often preferentially inherited,
deviating from usual Mendelian segregation. The balance between the so-called …

A male-biased sex-distorter gene drive for the human malaria vector Anopheles gambiae

A Simoni, AM Hammond, AK Beaghton, R Galizi… - Nature …, 2020 - nature.com
Only female insects transmit diseases such as malaria, dengue and Zika; therefore, control
methods that bias the sex ratio of insect offspring have long been sought. Genetic elements …

Spindle asymmetry drives non-Mendelian chromosome segregation

T Akera, L Chmátal, E Trimm, K Yang, C Aonbangkhen… - Science, 2017 - science.org
Genetic elements compete for transmission through meiosis, when haploid gametes are
created from a diploid parent. Selfish elements can enhance their transmission through a …

Combinations of Spok genes create multiple meiotic drivers in Podospora

AA Vogan, SL Ament-Velásquez, A Granger-Farbos… - Elife, 2019 - elifesciences.org
Meiotic drive is the preferential transmission of a particular allele during sexual reproduction.
The phenomenon is observed as spore killing in multiple fungi. In natural populations of …

[PDF][PDF] Evolutionary perspectives on germline-restricted chromosomes in flies (Diptera)

CN Hodson, L Ross - Genome Biology and Evolution, 2021 - academic.oup.com
In some eukaryotes, germline soma differentiation involves elimination of parts of the
genome from somatic cells. The portions of the genome restricted to the germline often …

Engineering the composition and fate of wild populations with gene drive

BA Hay, G Oberhofer, M Guo - Annual Review of Entomology, 2021 - annualreviews.org
Insects play important roles as predators, prey, pollinators, recyclers, hosts, parasitoids, and
sources of economically important products. They can also destroy crops; wound animals; …

Standard deviations: the biological bases of transmission ratio distortion

L Fishman, M McIntosh - Annual Review of Genetics, 2019 - annualreviews.org
The rule of Mendelian inheritance is remarkably robust, but deviations from the equal
transmission of alternative alleles at a locus [aka transmission ratio distortion (TRD)] are also …

Rapid evolution of a Y-chromosome heterochromatin protein underlies sex chromosome meiotic drive

Q Helleu, PR Gérard, R Dubruille… - Proceedings of the …, 2016 - National Acad Sciences
Sex chromosome meiotic drive, the non-Mendelian transmission of sex chromosomes, is the
expression of an intragenomic conflict that can have extreme evolutionary consequences …

[HTML][HTML] Gene drive through a landscape: reaction–diffusion models of population suppression and elimination by a sex ratio distorter

A Beaghton, PJ Beaghton, A Burt - Theoretical population biology, 2016 - Elsevier
Some genes or gene complexes are transmitted from parents to offspring at a greater-than-
Mendelian rate, and can spread and persist in populations even if they cause some harm to …