Cheating evolution: engineering gene drives to manipulate the fate of wild populations
Engineered gene drives—the process of stimulating the biased inheritance of specific genes—
have the potential to enable the spread of desirable genes throughout wild populations or to …
have the potential to enable the spread of desirable genes throughout wild populations or to …
B chromosomes–a matter of chromosome drive
A Houben - Frontiers in plant science, 2017 - frontiersin.org
B chromosomes are supernumerary chromosomes which are often preferentially inherited,
deviating from usual Mendelian segregation. The balance between the so-called …
deviating from usual Mendelian segregation. The balance between the so-called …
A male-biased sex-distorter gene drive for the human malaria vector Anopheles gambiae
Only female insects transmit diseases such as malaria, dengue and Zika; therefore, control
methods that bias the sex ratio of insect offspring have long been sought. Genetic elements …
methods that bias the sex ratio of insect offspring have long been sought. Genetic elements …
Spindle asymmetry drives non-Mendelian chromosome segregation
Genetic elements compete for transmission through meiosis, when haploid gametes are
created from a diploid parent. Selfish elements can enhance their transmission through a …
created from a diploid parent. Selfish elements can enhance their transmission through a …
Combinations of Spok genes create multiple meiotic drivers in Podospora
AA Vogan, SL Ament-Velásquez, A Granger-Farbos… - Elife, 2019 - elifesciences.org
Meiotic drive is the preferential transmission of a particular allele during sexual reproduction.
The phenomenon is observed as spore killing in multiple fungi. In natural populations of …
The phenomenon is observed as spore killing in multiple fungi. In natural populations of …
[PDF][PDF] Evolutionary perspectives on germline-restricted chromosomes in flies (Diptera)
In some eukaryotes, germline soma differentiation involves elimination of parts of the
genome from somatic cells. The portions of the genome restricted to the germline often …
genome from somatic cells. The portions of the genome restricted to the germline often …
Engineering the composition and fate of wild populations with gene drive
BA Hay, G Oberhofer, M Guo - Annual Review of Entomology, 2021 - annualreviews.org
Insects play important roles as predators, prey, pollinators, recyclers, hosts, parasitoids, and
sources of economically important products. They can also destroy crops; wound animals; …
sources of economically important products. They can also destroy crops; wound animals; …
Standard deviations: the biological bases of transmission ratio distortion
L Fishman, M McIntosh - Annual Review of Genetics, 2019 - annualreviews.org
The rule of Mendelian inheritance is remarkably robust, but deviations from the equal
transmission of alternative alleles at a locus [aka transmission ratio distortion (TRD)] are also …
transmission of alternative alleles at a locus [aka transmission ratio distortion (TRD)] are also …
Rapid evolution of a Y-chromosome heterochromatin protein underlies sex chromosome meiotic drive
Sex chromosome meiotic drive, the non-Mendelian transmission of sex chromosomes, is the
expression of an intragenomic conflict that can have extreme evolutionary consequences …
expression of an intragenomic conflict that can have extreme evolutionary consequences …
[HTML][HTML] Gene drive through a landscape: reaction–diffusion models of population suppression and elimination by a sex ratio distorter
A Beaghton, PJ Beaghton, A Burt - Theoretical population biology, 2016 - Elsevier
Some genes or gene complexes are transmitted from parents to offspring at a greater-than-
Mendelian rate, and can spread and persist in populations even if they cause some harm to …
Mendelian rate, and can spread and persist in populations even if they cause some harm to …