Drug repurposing: a new hope in drug discovery for prostate cancer

JA Malik, S Ahmed, SS Momin, S Shaikh, A Alafnan… - ACS …, 2022 - ACS Publications
Prostate cancer (PCA), the most common cancer in men, accounted for 1.3 million new
incidences in 2018. An increase in incidences is an issue of concern that should be …

[HTML][HTML] Anticancer properties of fenofibrate: a repurposing use

X Lian, G Wang, H Zhou, Z Zheng, Y Fu, L Cai - Journal of Cancer, 2018 - ncbi.nlm.nih.gov
Cancer is a leading cause of death throughout the world, and cancer therapy remains a big
medical challenge in terms of both its therapeutic efficacy and safety. Therefore, to find out a …

Molecular mechanisms of fenofibrate-induced metabolic catastrophe and glioblastoma cell death

A Wilk, D Wyczechowska, A Zapata… - … and cellular biology, 2015 - Am Soc Microbiol
Fenofibrate (FF) is a common lipid-lowering drug and a potent agonist of the peroxisome
proliferator-activated receptor alpha (PPARα). FF and several other agonists of PPARα have …

Fenofibrate induces apoptosis of triple-negative breast cancer cells via activation of NF-κB pathway

T Li, Q Zhang, J Zhang, G Yang, Z Shao, J Luo, M Fan… - BMC cancer, 2014 - Springer
Background There are a lot of unmet needs in patients with triple-negative breast cancer
(TNBC). Fenofibrate, a peroxisome proliferator-activated receptor alpha (PPAR-α) agonist …

Fenofibrate-induced nuclear translocation of FoxO3A triggers Bim-mediated apoptosis in glioblastoma cells in vitro

A Wilk, K Urbanska, M Grabacka, J Mullinax… - Cell cycle, 2012 - Taylor & Francis
Anti-neoplastic potential of calorie restriction or ligand-induced activation of peroxisome
proliferator activated receptors (PPARs) has been demonstrated in multiple studies; …

The role of connexins in prostate cancer promotion and progression

J Czyż, K Szpak, Z Madeja - Nature Reviews Urology, 2012 - nature.com
Prostate cancer is a prevalent disease that is characterized by a presumably long latency
period and a moderate propensity to metastasize. Although a range of mechanisms have …

AMPK‐dependent signaling modulates the suppression of invasion and migration by fenofibrate in CAL 27 oral cancer cells through NF‐κ B pathway

SC Tsai, MH Tsai, CF Chiu, CC Lu… - Environmental …, 2016 - Wiley Online Library
Fenofibrate, a peroxisome proliferator‐activated receptor alpha (PPARα) agonist and lipid‐
lowering agent, has been used worldwide for treatment of hyperlipidemia. The clinical trials …

Lipid-lowering drugs and cancer: an updated perspective

A Alizadehasl, MS Alavi, S Boudagh, MS Alavi… - Pharmacological …, 2024 - Springer
Statins and non-statin medications used for the management of dyslipidemia have been
shown to possess antitumor properties. Since the use of these drugs has steadily increased …

Fenofibrate augments the sensitivity of drug-resistant prostate cancer cells to docetaxel

M Luty, K Piwowarczyk, A Łabędź-Masłowska… - Cancers, 2019 - mdpi.com
Metronomic agents reduce the effective doses and adverse effects of cytostatics in cancer
chemotherapy. Therefore, they can enhance the treatment efficiency of drug-resistant …

Anti-glioblastoma effects of phenolic variants of benzoylphenoxyacetamide (BPA) with high potential for blood brain barrier penetration

J Stalinska, C Vittori, CH Ingraham IV, SC Carson… - Scientific Reports, 2022 - nature.com
Glioblastomas are the most aggressive brain tumors for which therapeutic options are
limited. Current therapies against glioblastoma include surgical resection, followed by …