Psychiatric face of COVID-19

L Steardo Jr, L Steardo, A Verkhratsky - Translational psychiatry, 2020 - nature.com
Abstract The Coronavirus Disease 2019 (COVID-19) represents a severe multiorgan
pathology which, besides cardio-respiratory manifestations, affects the function of the central …

Climate change, environment pollution, COVID-19 pandemic and mental health

D Marazziti, P Cianconi, F Mucci, L Foresi… - Science of the total …, 2021 - Elsevier
Converging data would indicate the existence of possible relationships between climate
change, environmental pollution and epidemics/pandemics, such as the current one due to …

Neurovascular dysfunction in GRN-associated frontotemporal dementia identified by single-nucleus RNA sequencing of human cerebral cortex

E Gerrits, LAA Giannini, N Brouwer, S Melhem… - Nature …, 2022 - nature.com
Frontotemporal dementia (FTD) is the second most prevalent form of early-onset dementia,
affecting predominantly frontal and temporal cerebral lobes. Heterozygous mutations in the …

[HTML][HTML] ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids

KR Bowles, MC Silva, K Whitney, T Bertucci, JE Berlind… - Cell, 2021 - cell.com
Frontotemporal dementia (FTD) because of MAPT mutation causes pathological
accumulation of tau and glutamatergic cortical neuronal death by unknown mechanisms. We …

Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases

JS Loh, WQ Mak, LKS Tan, CX Ng, HH Chan… - … and Targeted Therapy, 2024 - nature.com
The human gastrointestinal tract is populated with a diverse microbial community. The vast
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …

Frontotemporal dementia, where do we stand? A narrative review

A Antonioni, EM Raho, P Lopriore, AP Pace… - International journal of …, 2023 - mdpi.com
Frontotemporal dementia (FTD) is a neurodegenerative disease of growing interest, since it
accounts for up to 10% of middle-age-onset dementias and entails a social, economic, and …

Neuroinflammation: a potential risk for dementia

MA Ahmad, O Kareem, M Khushtar, M Akbar… - International journal of …, 2022 - mdpi.com
Dementia is a neurodegenerative condition that is considered a major factor contributing to
cognitive decline that reduces independent function. Pathophysiological pathways are not …

A predictive coding framework of allostatic–interoceptive overload in frontotemporal dementia

JA Migeot, CA Duran-Aniotz, CM Signorelli… - Trends in …, 2022 - cell.com
Recent allostatic–interoceptive explanations using predictive coding models propose that
efficient regulation of the body's internal milieu is necessary to correctly anticipate …

Creutzfeldt-Jakob disease in a man with COVID-19: SARS-CoV-2-accelerated neurodegeneration?

MJ Young, M O'Hare, M Matiello… - Brain, Behavior, and …, 2020 - Elsevier
We describe a man whose first manifestations of Creutzfeldt-Jakob disease occurred in
tandem with symptomatic onset of coronavirus disease 2019 (COVID-19). Drawing from …

Extracellular tau stimulates phagocytosis of living neurons by activated microglia via Toll-like 4 receptor–NLRP3 inflammasome–caspase-1 signalling axis

K Pampuscenko, R Morkuniene, L Krasauskas… - Scientific reports, 2023 - nature.com
In tauopathies, abnormal deposition of intracellular tau protein followed by gradual elevation
of tau in cerebrospinal fluids and neuronal loss has been documented, however, the …