Reactive oxygen species (ROS) have been shown to be toxic but also function as signalling
molecules. This biological paradox underlies mechanisms that are important for the integrity …

The transition or d-block metal ions manganese, iron, cobalt, nickel, copper, zinc and to a
more specialized degree molybdenum, tungsten, and vanadium have been shown to be …

The generation of reactive oxygen species (ROS) is inevitably linked to life. However, the
precise role of ROS in signalling and specific targets is largely unknown. We perform a …

Period (PER) proteins are essential components of the mammalian circadian clock. They
form complexes with cryptochromes (CRY), which negatively regulate CLOCK/BMAL1 …

Metallothioneins (MTs) were discovered more than 50 years ago and identified as low‐
molecular weight, sulfhydryl‐rich proteins that were subsequently found to bind zinc …

Cellular signal transduction pathways are influenced by the zinc and redox status of the cell.
Numerous chronic diseases, including cardiovascular disease (CVD) and diabetes mellitus …

The carcinogenicity of cadmium, arsenic, and chromium (VI) compounds has been
recognized for some decades. However, the underlying molecular mechanisms seem to be …

A transcriptional response to singlet oxygen in Rhodobacter sphaeroides is controlled by the
group IV σ factor σ E and its cognate anti-σ ChrR. Crystal structures of the σ E/ChrR complex …

Redox regulation of stress proteins, such as molecular chaperones, guarantees an
immediate response to oxidative stress conditions. This review focuses on the two major …

Despite zinc ions being redox inert in biologic systems, zinc-finger structures act as redox-
sensitive molecular switches controlling several crucial cellular processes. Oxidative or …