Cholesterol is an essential component of both the peripheral nervous system and central
nervous system (CNS) of mammals. Brain cholesterol is synthesized in situ by astrocytes …

Lipoproteins in plasma transport lipids between tissues, however, only high-density
lipoproteins (HDL) appear to traverse the blood–brain barrier (BBB); thus, lipoproteins found …

The blood–brain barrier (BBB) is a dynamic and complex interface between the blood and
the central nervous system regulating brain homeostasis. Major functions of the BBB include …

The incidence of metabolic disorders, as well as of neurodegenerative diseases—mainly the
sporadic forms of Alzheimer's and Parkinson's disease—are increasing worldwide. Notably …

There is considerable evidence showing that the neurodegenerative processes that lead to
sporadic Parkinson's disease (PD) begin many years before the appearance of the …

Background: Evidence has revealed an association between familial hypercholesterolemia
and cognitive impairment. In this regard, a connection between cognitive deficits and …

The presence of insoluble aggregates of amyloid β (Aβ) in the form of neuritic plaques (NPs)
is one of the main features that define Alzheimer's disease. Studies have suggested that the …

Background: Memory-impairment was one of the common characteristics in patients with
diabetes mellitus. The release of chronic inflammation mediators and insulin resistance in …

The low-density-lipoprotein receptor (LDLr) removes low-density lipoprotein (LDL), an
endovascular transporter that carries cholesterol from the bloodstream to peripheral tissues …

The biological fates of the key initiator of Alzheimer's disease (AD), the amyloid precursor
protein (APP), and a family of lipoprotein receptors, the low-density lipoprotein (LDL) …