Oxidative stress, a term that describes the imbalance between oxidants and antioxidants,
leads to the disruption of redox signals and causes molecular damage. Increased oxidative …

Sarcopenia represents a muscle-wasting syndrome characterized by progressive and
generalized degenerative loss of skeletal muscle mass, quality, and strength occurring …

The mTOR (mechanistic target of rapamycin) is a master regulator of several crucial cellular
processes, including protein synthesis, cellular growth, proliferation, autophagy, lysosomal …

Abstract Glycogen synthase kinase-3 (GSK3) may be the busiest kinase in most cells, with
over 100 known substrates to deal with. How does GSK3 maintain control to selectively …

Age is the most important risk factor for most diseases. Mitochondria play a central role in
bioenergetics and metabolism. In addition, several lines of evidence indicate the impact of …

Abstract Glycogen synthase kinase‐3 (GSK3) is a highly evolutionarily conserved
serine/threonine protein kinase first identified as an enzyme that regulates glycogen …

The aging population is increasing in developed countries. Because the incidence of
cardiac disease increases dramatically with age, it is important to understand the molecular …

Emerging insights into cellular senescence highlight the relevance of senescence in
musculoskeletal disorders, which represent the leading global cause of disability. Cellular …

Cardiovascular diseases are the most prominent maladies in aging societies. Indeed, aging
promotes the structural and functional declines of both the heart and the blood circulation …

The protein kinase mammalian or mechanistic target of rapamycin (mTOR) is an atypical
serine/threonine kinase that exerts its main cellular functions by interacting with specific …