Epilepsy is a paroxysmal brain disorder that results from an imbalance between neuronal
excitation and inhibition. Gamma-aminobutyric acid (GABA) is the most important inhibitory …

Normal brain function requires a tightly regulated balance between excitatory and inhibitory
neurotransmissions. γ‐Aminobutyric acid type A (GABAA) receptors represent the major …

Objective Epilepsy of infancy with migrating focal seizures (EIMFS) is one of the most severe
developmental and epileptic encephalopathies. We delineate the genetic causes and …

The RNA editing enzyme ADAR2 is essential for the recoding of brain transcripts. Impaired
ADAR2 editing leads to early-onset epilepsy and premature death in a mouse model. Here …

Febrile seizures (FS) are the most common form of epilepsy in children between six months
and five years of age. FS is a self-limited type of fever-related seizure. However, complicated …

Epilepsy is one of the most common episodic neurological disorders, affecting 1%
population worldwide. The genetic variations of γ-aminobutyric acid type A (GABA A) …

Drugs that modulate the GABAA receptor are widely used in clinical practice for both the
long-term management of epilepsy and emergency seizure control. In addition to older …

Next-generation sequencing (NGS) technology has led to great advances in understanding
the causes of Mendelian and complex neurological diseases. Owing to the complexity of …

Objective This study aimed to obtain a comprehensive understanding of the genetic and
phenotypic aspects of GABRG2-related epilepsy and its prognosis and to explore the …

Background The genetic architecture of non-acquired focal epilepsies (NAFEs) becomes
increasingly unravelled using genome-wide sequencing datasets. However, it remains to be …