Activating receptor tyrosine kinase RET (rarranged during transfection) gene alterations
have been identified as oncogenic in multiple malignancies. RET gene rearrangements …

The rearranged during transfection (RET) proto-oncogene was identified in 1985 and, very
soon thereafter, a rearrangement named RET/PTC was discovered in papillary thyroid …

BTA_Guidelines_for_the_Management_of_Thyroid Cancer_E Page 1 CLINICAL
ENDOCRINOLOGY VOLUME 81 SUPPLEMENT 1 JULY 2014 THE CLINICAL JOURNAL OF …

Context: Over the last decade, our knowledge of the multiple endocrine neoplasia (MEN)
type 2 syndromes MEN2A and MEN2B and familial medullary thyroid carcinoma (FMTC) has …

Purpose: Positive results of phase I studies evaluating lenvatinib in solid tumors, including
thyroid cancer, prompted a phase II trial in advanced medullary thyroid carcinoma (MTC) …

Abstract The guidelines Thyroid Cancer 2022 are prepared based on previous Polish
recommendations updated in 2018. They consider international guidelines—American …

Background: Pathogenic germline mutations affecting the RET proto-oncogene underlie the
development of hereditary medullary thyroid carcinoma (MTC). The aims of this study were …

Background: A limited number of approved therapeutic options are available to metastatic
medullary thyroid cancer (MTC) patients, and the response to conventional chemotherapy …

Medullary thyroid carcinoma (MTC) and the multiple endocrine neoplasia (MEN) type 2
syndromes are rare but important endocrine diseases that are increasingly managed by …

Twenty-five percent of medullary thyroid cancers (MTC) are familial and inherited as an
autosomal dominant trait. Three different phenotypes can be distinguished: multiple …