Intervertebral disc (IVD) degeneration (IDD) is a pathological process that commonly occurs
throughout the human life span and is a major cause of lower back pain. Better elucidation …

Advanced age is the greatest risk factor for the majority of human ailments, including spine‐
related chronic disability and back pain, which stem from age‐associated intervertebral disc …

Mechanical loading of the intervertebral disc (IVD) initiates cell‐mediated remodeling events
that contribute to disc degeneration. Cells of the IVD, nucleus pulposus (NP) and anulus …

Lumbar intervertebral disc herniation, as a leading cause of low back pain, productivity loss,
and disability, is a common musculoskeletal disorder that results in significant …

Intervertebral disc degeneration is a well-known cause of disability, the result of which
includes neck and back pain with associated mobility limitations. The purpose of this article …

Increased tissue stiffness is associated with various pathological processes, such as fibrosis,
inflammation, and aging. The matrix stiffness of the nucleus pulposus (NP) tissues increases …

Background Extracellular matrix stiffness is emerging as a crucial mechanical cue that drives
the progression of various diseases, such as cancer, fibrosis, and inflammation. The matrix …

Osteoarthritis (OA) and chronic low back pain due to degenerative (intervertebral) disc
disease (DDD) are two of the major causes of disabilities worldwide, affecting hundreds of …

Introduction In this study, magnetic resonance imaging data was used to (1) model IVD‐
specific gradients of glucose, oxygen, lactate, and pH; and (2) investigate possible effects of …

Low back pain is often caused by intervertebral disc degeneration, which is characterized by
nucleus pulposus (NP) and extracellular matrix (ECM) degeneration. Human adipose …