[HTML][HTML] The proteolysis of ECM in intervertebral disc degeneration
Intervertebral disc (IVD) degeneration (IDD) is a pathological process that commonly occurs
throughout the human life span and is a major cause of lower back pain. Better elucidation …
throughout the human life span and is a major cause of lower back pain. Better elucidation …
Molecular mechanisms of biological aging in intervertebral discs
NV Vo, RA Hartman, PR Patil… - Journal of …, 2016 - Wiley Online Library
Advanced age is the greatest risk factor for the majority of human ailments, including spine‐
related chronic disability and back pain, which stem from age‐associated intervertebral disc …
related chronic disability and back pain, which stem from age‐associated intervertebral disc …
Mechanotransduction and cell biomechanics of the intervertebral disc
Mechanical loading of the intervertebral disc (IVD) initiates cell‐mediated remodeling events
that contribute to disc degeneration. Cells of the IVD, nucleus pulposus (NP) and anulus …
that contribute to disc degeneration. Cells of the IVD, nucleus pulposus (NP) and anulus …
Understanding the etiopathogenesis of lumbar intervertebral disc herniation: From clinical evidence to basic scientific research
M Zhou, AA Theologis, GD O'Connell - JOR spine, 2024 - Wiley Online Library
Lumbar intervertebral disc herniation, as a leading cause of low back pain, productivity loss,
and disability, is a common musculoskeletal disorder that results in significant …
and disability, is a common musculoskeletal disorder that results in significant …
Molecular mechanisms of intervertebral disc degeneration
SM Rider, S Mizuno, JD Kang - Spine surgery and related research, 2019 - jstage.jst.go.jp
Intervertebral disc degeneration is a well-known cause of disability, the result of which
includes neck and back pain with associated mobility limitations. The purpose of this article …
includes neck and back pain with associated mobility limitations. The purpose of this article …
Stiff substrate induces nucleus pulposus cell ferroptosis via YAP and N‐cadherin mediated mechanotransduction
W Ke, Z Liao, H Liang, B Tong, Y Song… - Advanced …, 2023 - Wiley Online Library
Increased tissue stiffness is associated with various pathological processes, such as fibrosis,
inflammation, and aging. The matrix stiffness of the nucleus pulposus (NP) tissues increases …
inflammation, and aging. The matrix stiffness of the nucleus pulposus (NP) tissues increases …
[HTML][HTML] Matrix stiffness induces Drp1-mediated mitochondrial fission through Piezo1 mechanotransduction in human intervertebral disc degeneration
W Ke, B Wang, Z Liao, Y Song, G Li, L Ma… - Journal of Translational …, 2023 - Springer
Background Extracellular matrix stiffness is emerging as a crucial mechanical cue that drives
the progression of various diseases, such as cancer, fibrosis, and inflammation. The matrix …
the progression of various diseases, such as cancer, fibrosis, and inflammation. The matrix …
Injectable hydrogels for articular cartilage and nucleus pulposus repair: status quo and prospects
Osteoarthritis (OA) and chronic low back pain due to degenerative (intervertebral) disc
disease (DDD) are two of the major causes of disabilities worldwide, affecting hundreds of …
disease (DDD) are two of the major causes of disabilities worldwide, affecting hundreds of …
Patient‐specific apparent diffusion maps used to model nutrient availability in degenerated intervertebral discs
W Shalash, SR Ahrens, LA Bardonova… - JOR …, 2021 - Wiley Online Library
Introduction In this study, magnetic resonance imaging data was used to (1) model IVD‐
specific gradients of glucose, oxygen, lactate, and pH; and (2) investigate possible effects of …
specific gradients of glucose, oxygen, lactate, and pH; and (2) investigate possible effects of …
Sustained release of GDF5 from a designed coacervate attenuates disc degeneration in a rat model
J Zhu, K Xia, W Yu, Y Wang, J Hua, B Liu, Z Gong… - Acta biomaterialia, 2019 - Elsevier
Low back pain is often caused by intervertebral disc degeneration, which is characterized by
nucleus pulposus (NP) and extracellular matrix (ECM) degeneration. Human adipose …
nucleus pulposus (NP) and extracellular matrix (ECM) degeneration. Human adipose …