Flavonoids are plant pigments that are synthesised from phenylalanine, generally display
marvelous colors known from flower petals, mostly emit brilliant fluorescence when they are …

Covalent attachment of myristate and/or palmitate occurs on a wide variety of viral and
cellular proteins. This review will highlight the latest advances in our understanding of the …

The human immunodeficiency virus (HIV) genome encodes a total of three structural
proteins, two envelope proteins, three enzymes, and six accessory proteins. Studies over the …

The human immunodeficiency virus type 1 (HIV-1) matrix protein forms a structural shell
associated with the inner viral membrane and performs other essential functions throughout …

Enveloped viruses mature by budding at cellular membranes. It has been generally thought
that this process is driven by interactions between the viral transmembrane proteins and the …

One of the core standards of biochemistry is that the function of a protein relies on its 3D
structure. This idea posits that all the information required for a protein to perform its …

The myristoylated matrix protein (myr-MA) of HIV functions as a regulator of intracellular
localization, targeting the Gag precursor polyprotein to lipid rafts in the plasma membrane …

We recently demonstrated that a single amino acid substitution in matrix residue 12 (12LE)
or 30 (30LE) blocks the incorporation of human immunodeficiency virus type 1 (HIV-1) …

After budding, the human immunodeficiency virus (HIV) must 'mature'into an infectious viral
particle. Viral maturation requires proteolytic processing of the Gag polyprotein at the matrix …

Incorporation of envelope glycoproteins into a budding retrovirus is an essential step in the
formation of an infectious virus particle. By using site-directed mutagenesis, we identified …