Much has been written about the functions of the E2F transcription factor and the product of
the retinoblastoma tumor suppressor gene (pRB). These proteins have been described in …

Transcriptional control during the G 1/S transition is important in regulating cell cycle
progression. The transcription factor DRTF1/E2F is believed to play a crucial role in this …

The mammalian transcription factor E2F plays an important role in regulating the expression
of genes that are required for passage through the cell cycle. This transcriptional activity is …

The E2F DNA binding activity consists of a heterodimer between E2F and DP family
proteins, and these interactions are required for association of E2F proteins with pRb and …

Genetic evidence from retinoblastoma patients and experiments describing the mechanism
of cellular transformation by the DNA tumor viruses have defined a central role for the …

Unregulated expression of the transcription factor E2F promotes the G 1-to-S phase
transition in cultured mammalian cells. However, there has been no direct evidence for an …

The product of the retinoblastoma tumor-suppressor gene (RB) is a ubiquitously expressed,
105-kDa nuclear phosphoprotein (pRB). The pRB protein negatively regulates the cellular G …

Activation of heterodimeric E2F-DP transcription factors can drive the G1-S transition.
Mutation of the Drosophila melanogaster dE2F gene eliminates transcriptional activation of …

E2F/DP complexes play a pivotal role in the regulation of the G1/S transition in animals.
Recently, plant E2F homologs have been cloned, but DP‐related sequences have not been …

B-myb belongs to a group of cell cycle genes whose transcription is repressed in G0/early
G1 through a binding site for the transcription factor E2F. Here, we show that the B-myb …