Many drugs and other xenobiotics (eg, preservatives, insecticides, and plastifiers) contain
hydrolyzable moieties such as ester or amide groups. In biological media, such foreign …

Indenoisoquinoline topoisomerase I (Top1) inhibitors are a novel class of anticancer agents
with two compounds in clinical trials. Recent metabolism studies of indotecan (LMP400) led …

Biphenyl hydrolase-like protein (BPHL, NCBI accession number NP_004323) is a novel
human serine hydrolase recently identified as a human valacyclovirase, catalyzing the …

A structure–activity relationship study for a series of vitamin D3-based (VD3) analogues that
incorporate aromatic A-ring mimics with varying functionality has provided key insight into …

Purpose. The aim of this study is to investigate species differences in the stereoselective
hydrolysis for propranolol ester prodrugs in mammalian intestinal mucosa and Caco-2 cells …

A series of dichloro (ethylenediamine)-type platinum complexes bearing ester-, amide-and
ether-bonded alkyl straight chains (C2–C18) was prepared as a model for the prodrug of cis …

The stereoselective hydrolysis of esmolol in whole blood and in its separated components
from rat, rabbit and human was investigated. Blood esterase activities were variable in …

(±)-Ethyl 2-fluoro-2-phenylacetate was stereoselectively hydrolyzed by cultured cells of
several rat cancer cell lines to give the carboxylic acid rich in the R enantiomer. The …

Esterases in normal hamster pancreas and pancreatic tubular adenocarcinoma of ductal
origin induced by N-nitrosobis (2-oxopropyl) amine were stained in cryostat sections with …