At the interface of sensory and motor dysfunctions and Alzheimer's disease

MW Albers, GC Gilmore, J Kaye, C Murphy… - Alzheimer's & …, 2015 - Elsevier
Recent evidence indicates that sensory and motor changes may precede the cognitive
symptoms of Alzheimer's disease (AD) by several years and may signify increased risk of …

Olfactory dysfunction in neurodegenerative diseases

C Marin, D Vilas, C Langdon, I Alobid… - Current allergy and …, 2018 - Springer
Abstract Purpose of Review The sense of smell is today one of the focuses of interest in
aging and neurodegenerative disease research. In several neurodegenerative diseases …

ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models

PE Cramer, JR Cirrito, DW Wesson, CYD Lee, JC Karlo… - science, 2012 - science.org
Alzheimer's disease (AD) is associated with impaired clearance of β-amyloid (Aβ) from the
brain, a process normally facilitated by apolipoprotein E (apoE). ApoE expression is …

[HTML][HTML] The olfactory bulb as the entry site for prion-like propagation in neurodegenerative diseases

NL Rey, DW Wesson, P Brundin - Neurobiology of disease, 2018 - Elsevier
Olfactory deficits are present in numerous neurodegenerative disorders and are
accompanied by pathology in related brain regions. In several of these disorders, olfactory …

Olfaction in Parkinson's disease and related disorders

RL Doty - Neurobiology of disease, 2012 - Elsevier
Olfactory dysfunction is an early 'pre-clinical'sign of Parkinson's disease (PD). The present
review is a comprehensive and up-to-date assessment of such dysfunction in PD and …

Olfactory bulb involvement in neurodegenerative diseases

J Attems, L Walker, KA Jellinger - Acta neuropathologica, 2014 - Springer
Olfactory dysfunction is a common and early symptom of many neurodegenerative diseases,
particularly of Parkinson's disease and other synucleinopathies, Alzheimer's disease (AD) …

Innovative diagnostic tools for early detection of Alzheimer's disease

C Laske, HR Sohrabi, SM Frost, K López-de-Ipiña… - Alzheimer's & …, 2015 - Elsevier
Current state-of-the-art diagnostic measures of Alzheimer's disease (AD) are invasive
(cerebrospinal fluid analysis), expensive (neuroimaging) and time-consuming …

Cortical processing of odor objects

DA Wilson, RM Sullivan - Neuron, 2011 - cell.com
Natural odors, generally composed of many monomolecular components, are analyzed by
peripheral receptors into component features and translated into spatiotemporal patterns of …

When neurogenesis encounters aging and disease

O Lazarov, MP Mattson, DA Peterson… - Trends in …, 2010 - cell.com
In this review, we consider the evidence that a reduction in neurogenesis underlies aging-
related cognitive deficits and impairments in disorders such as Alzheimer's disease (AD) …

The microbiome and disease: reviewing the links between the oral microbiome, aging, and Alzheimer's disease

DK Shoemark, SJ Allen - Journal of Alzheimer's disease, 2014 - journals.sagepub.com
This review, gathered from diverse sources, shows how our microbiome influences health
and ultimately how well we age. Evidence linking oral bacteria to Alzheimer's disease (AD) …