Kinins are endogenous peptides that belong to the kallikrein-kinin system, which has been
extensively studied for over a century. Their essential role in multiple physiological and …

Introduction: Kinins are peptide mediators exerting their pro-inflammatory actions by the
selective stimulation of two distinct G-protein coupled receptors, termed BKB1R and BKB2R …

Nod-like receptor protein 3 (NLRP3)-mediated pyroptosis has a causal role in the
pathogenesis of gout. P2Y14 receptor (P2Y14R) distributed in immune cells including …

The initiation or progression of periodontitis might involve a local renin-angiotensin system
(RAS) in periodontal tissue. The aim of this study was to further characterize the local RAS in …

Background Gout is an inflammatory arthritis caused by monosodium urate monohydrate
(MSU) crystals' joint deposition. MSU phagocytosis by resident macrophages is a key step in …

Acute gout arthritis is one of the most painful inflammatory conditions. Treatments for gout
pain are limited to colchicine, nonsteroidal anti‐inflammatory drugs, and corticosteroids …

Fibromyalgia is a disease characterised as generalised chronic primary pain that causes
functional disability and a reduction in patients' quality of life, without specific …

Pain caused by the tumor or aromatase inhibitors (AIs) is a disabling symptom in breast
cancer survivors. Their mechanisms are unclear, but pro-algesic and inflammatory …

CD13, an ectoenzyme on myeloid and stromal cells, also circulates as a shed, soluble
protein (sCD13) with powerful chemoattractant, angiogenic, and arthritogenic properties …

Introduction Gout arthritis (GA) is an intermittent inflammatory disease affecting
approximately 10% of the worldwide population. Symptomatic phases (acute flares) are …