Alzheimer's Disease (AD) therapeutics based on the amyloid hypothesis have repeatedly
failed in clinical trials. Together with numerous reports that amyloid is present in brains from …

Medial temporal lobe dependent cognitive functions are highly vulnerable to hypoxia in the
hippocampal region, yet little is known about the relationship between the richness of …

INTRODUCTION There is no consensus on either the definition of successful cognitive
aging (SA) or the underlying neural mechanisms. METHODS We examined the agreement …

Despite its devastating clinical and societal impact, approaches to treat delirium in older
adults remain elusive, making it important to identify factors that may confer resilience to this …

Previous studies have introduced the concept of “SuperAgers,” defined as older adults with
youthful memory performance associated with the increased cortical thickness of the anterior …

Superagers are defined as older adults who have youthful memory performance
comparable to that of middle-aged adults. Classifying superagers based on the brain …

Introduction Genome‐wide association studies (GWAS) for late onset Alzheimer's disease
(AD) may miss genetic variants relevant for delineating disease stages when using clinically …

There exists a group of older individuals who appear to be resistant to age-related memory
decline. These “SuperAgers” have been shown to demonstrate preservation of cortical …

Superagers are older adults who maintain youthful memory despite advanced age. Previous
studies showed that superagers exhibit greater structural and intrinsic functional brain …

Age-related cortical atrophy and cognitive decline, especially in memory function, are
common among older adults. However, a subset of older adults, known as SuperAgers (SA) …