Giant virus biology and diversity in the era of genome-resolved metagenomics
The discovery of giant viruses, with capsids as large as some bacteria, megabase-range
genomes and a variety of traits typically found only in cellular organisms, was one of the …
genomes and a variety of traits typically found only in cellular organisms, was one of the …
The logic of virus evolution
Viruses are obligate intracellular parasites. Despite their dependence on host cells, viruses
are evolutionarily autonomous, with their own genomes and evolutionary trajectories locked …
are evolutionarily autonomous, with their own genomes and evolutionary trajectories locked …
The astounding world of glycans from giant viruses
Viruses are a heterogeneous ensemble of entities, all sharing the need for a suitable host to
replicate. They are extremely diverse, varying in morphology, size, nature, and complexity of …
replicate. They are extremely diverse, varying in morphology, size, nature, and complexity of …
Giant variations in giant virus genome packaging
PB Talbert, S Henikoff, KJ Armache - Trends in biochemical sciences, 2023 - cell.com
Giant viruses (Nucleocytoviricota) have a largely conserved lifecycle, yet how they cram their
large genomes into viral capsids is mostly unknown. The major capsid protein and the …
large genomes into viral capsids is mostly unknown. The major capsid protein and the …
The giant mimivirus 1.2 Mb genome is elegantly organized into a 30-nm diameter helical protein shield
A Villalta, A Schmitt, LF Estrozi, ERJ Quemin… - Elife, 2022 - elifesciences.org
Mimivirus is the prototype of the Mimiviridae family of giant dsDNA viruses. Little is known
about the organization of the 1.2 Mb genome inside the membrane-limited nucleoid filling …
about the organization of the 1.2 Mb genome inside the membrane-limited nucleoid filling …
Living virus‐based nanohybrids for biomedical applications
L Jin, Z Mao - Wiley Interdisciplinary Reviews: Nanomedicine …, 2024 - Wiley Online Library
Living viruses characterized by distinctive biological functions including specific targeting,
gene invasion, immune modulation, and so forth have been receiving intensive attention …
gene invasion, immune modulation, and so forth have been receiving intensive attention …
Giant viruses of the Megavirinae subfamily possess biosynthetic pathways to produce rare bacterial-like sugars in a clade-specific manner
The recent discovery that giant viruses encode proteins related to sugar synthesis and
processing paved the way for the study of their glycosylation machinery. We focused on the …
processing paved the way for the study of their glycosylation machinery. We focused on the …
Impact of glycosylation on viral vaccines
A Lembo, A Molinaro, C De Castro, F Berti… - Carbohydrate …, 2024 - Elsevier
Glycosylation is the most prominent modification important for vaccines and its specific
pattern depends on several factors that need to be considered when developing a new …
pattern depends on several factors that need to be considered when developing a new …
The giant Mimivirus 1.2 Mb genome is elegantly organized into a 30 nm helical protein shield
A Villalta, A Schmitt, LF Estrozi, ERJ Quemin… - bioRxiv, 2022 - biorxiv.org
Mimivirus is the prototype of the Mimiviridae family of giant dsDNA viruses. Little is known
about the organization of the 1.2 Mb genome inside the membrane-limited nucleoid filling …
about the organization of the 1.2 Mb genome inside the membrane-limited nucleoid filling …
Surface fibrils on the particles of nucleocytoviruses: A review
ILM Aquino, MG Barcelos… - Experimental …, 2023 - journals.sagepub.com
The capsid has a central role in viruses' life cycle. Although one of its major functions is to
protect the viral genome, the capsid may be composed of elements that, at some point …
protect the viral genome, the capsid may be composed of elements that, at some point …