The generation of the components that make up the embryonic body axis, such as the spinal
cord and vertebral column, takes place in an anterior-to-posterior (head-to-tail) direction …

Body axis elongation and segmentation are major morphogenetic events that take place
concomitantly during vertebrate embryonic development. Establishment of the final body …

Integrated in vitro models of human organogenesis are needed to elucidate the multi-
systemic events underlying development and disease. Here we report the generation of …

We previously demonstrated that long non-coding RNA cytoskeleton regulator RNA
(CYTOR), also known as Linc00152, was significantly overexpressed in colon cancer and …

Transcription factors are crucial drivers of cellular differentiation during animal development
and often share ancient evolutionary origins. The T-box transcription factor Brachyury plays …

During early development the vertebrate embryo elongates through a combination of tissue
shape change, growth and progenitor cell expansion across multiple regions of the body …

The development of the vertebrate spinal cord involves the formation of the neural tube and
the generation of multiple distinct cell types. The process starts during gastrulation …

The human spinal column is a dynamic, segmented, bony, and cartilaginous structure that
protects the neurologic system and simultaneously provides balance and flexibility. Children …

The vertebrate anteroposterior axis forms through elongation of multiple tissues during
embryogenesis. This process is based on tissue-autonomous mechanisms of force …

Although cell-to-cell heterogeneity in gene and protein expression within cell populations
has been widely documented, we know little about its biological functions. By studying …