Polymeric nanomedicines for the treatment of hepatic diseases

F Luo, Y Yu, M Li, Y Chen, P Zhang, C Xiao… - Journal of …, 2022 - Springer
The liver is an important organ in the human body and performs many functions, such as
digestion, detoxification, metabolism, immune responses, and vitamin and mineral storage …

Understanding the potential role of nanotechnology in liver fibrosis: a paradigm in therapeutics

S Singh, N Sharma, S Shukla, T Behl, S Gupta… - Molecules, 2023 - mdpi.com
The liver is a vital organ that plays a crucial role in the physiological operation of the human
body. The liver controls the body's detoxification processes as well as the storage and …

Carbon Nitride‐Based siRNA Vectors with Self‐Produced O2 Effects for Targeting Combination Therapy of Liver Fibrosis via HIF‐1α‐Mediated TGF‐β1/Smad …

MX Liu, L Xu, YT Cai, RJ Wang, YY Gu… - Advanced …, 2023 - Wiley Online Library
Hypoxia is an important feature, which can upregulate the hypoxia‐inducible factor‐1α (HIF‐
1α) expression and promote the activation of hepatic stellate cells (HSCs), leading to liver …

Novel mucoadhesive celecoxib-loaded cubosomal sponges: Anticancer potential and regulation of myeloid-derived suppressor cells in oral squamous cell carcinoma

AA Mabrouk, NS El-Mezayen, MI Tadros… - European Journal of …, 2023 - Elsevier
Oral squamous-cell carcinoma (OSCC) is a widespread health problem. Myeloid-derived
suppressor cells (MDSCs) are major tumor microenvironment (TME) population that govern …

[HTML][HTML] Surface modified genistein phytosome for breast cancer treatment: In-vitro appraisal, pharmacokinetics, and in-vivo antitumor efficacy

IA Komeil, OY Abdallah, WM El-Refaie - European Journal of …, 2022 - Elsevier
Based on phytosomes advantages over liposomes, hyaluronic acid (HA) with/out pegylated
phospholipid was used to develop surface-modified genistein (Gen) phytosome as Gen …

[HTML][HTML] Potentialities of nanomaterials for the management and treatment of metabolic syndrome: A new insight

CO Adetunji, OS Michael, S Rathee, KRB Singh… - Materials today …, 2022 - Elsevier
Metabolic syndrome is a collection of abnormalities including insulin resistance,
hypertension, dyslipidemia, type 2 diabetes, obesity, inflammation, non-alcoholic fatty liver …

[HTML][HTML] Design, synthesis, docking and mechanistic studies of new thiazolyl/thiazolidinylpyrimidine-2, 4-dione antiproliferative agents

AA Aly, MB Alshammari, A Ahmad, HAM Gomaa… - Arabian Journal of …, 2023 - Elsevier
In this article, we display on the synthesis and biological evaluation of a new series of
thiazolylpyrimidine 3a-l and thiazolidinylpyrimidine derivatives 5a-e. The structures of the …

Zein/phospholipid composite nanoparticles for successful delivery of gallic acid into ahscs: Influence of size, surface charge, and vitamin a coupling

SAA Radwan, WH El-Maadawy, C Yousry… - International journal …, 2020 - Taylor & Francis
Purpose Zein/phospholipid composite nanoparticles (CNPs) were developed as a delivery
platform for gallic acid (GA), a polyphenolic compound with reported preclinical antifibrotic …

Prospective therapeutics for intestinal and hepatic fibrosis

X Li, M Yu, Q Zhao, Y Yu - Bioengineering & translational …, 2023 - Wiley Online Library
Currently, there are no effective therapies for intestinal and hepatic fibrosis representing a
considerable unmet need. Breakthroughs in pathogenesis have accelerated the …

Recent advances in nanomedicine for the diagnosis and therapy of liver fibrosis

X Bai, G Su, S Zhai - Nanomaterials, 2020 - mdpi.com
Liver fibrosis, a reversible pathological process of inflammation and fiber deposition caused
by chronic liver injury and can cause severe health complications, including liver failure …