Polymeric nanomedicines for the treatment of hepatic diseases
The liver is an important organ in the human body and performs many functions, such as
digestion, detoxification, metabolism, immune responses, and vitamin and mineral storage …
digestion, detoxification, metabolism, immune responses, and vitamin and mineral storage …
Understanding the potential role of nanotechnology in liver fibrosis: a paradigm in therapeutics
The liver is a vital organ that plays a crucial role in the physiological operation of the human
body. The liver controls the body's detoxification processes as well as the storage and …
body. The liver controls the body's detoxification processes as well as the storage and …
Carbon Nitride‐Based siRNA Vectors with Self‐Produced O2 Effects for Targeting Combination Therapy of Liver Fibrosis via HIF‐1α‐Mediated TGF‐β1/Smad …
MX Liu, L Xu, YT Cai, RJ Wang, YY Gu… - Advanced …, 2023 - Wiley Online Library
Hypoxia is an important feature, which can upregulate the hypoxia‐inducible factor‐1α (HIF‐
1α) expression and promote the activation of hepatic stellate cells (HSCs), leading to liver …
1α) expression and promote the activation of hepatic stellate cells (HSCs), leading to liver …
Novel mucoadhesive celecoxib-loaded cubosomal sponges: Anticancer potential and regulation of myeloid-derived suppressor cells in oral squamous cell carcinoma
AA Mabrouk, NS El-Mezayen, MI Tadros… - European Journal of …, 2023 - Elsevier
Oral squamous-cell carcinoma (OSCC) is a widespread health problem. Myeloid-derived
suppressor cells (MDSCs) are major tumor microenvironment (TME) population that govern …
suppressor cells (MDSCs) are major tumor microenvironment (TME) population that govern …
[HTML][HTML] Surface modified genistein phytosome for breast cancer treatment: In-vitro appraisal, pharmacokinetics, and in-vivo antitumor efficacy
Based on phytosomes advantages over liposomes, hyaluronic acid (HA) with/out pegylated
phospholipid was used to develop surface-modified genistein (Gen) phytosome as Gen …
phospholipid was used to develop surface-modified genistein (Gen) phytosome as Gen …
[HTML][HTML] Potentialities of nanomaterials for the management and treatment of metabolic syndrome: A new insight
Metabolic syndrome is a collection of abnormalities including insulin resistance,
hypertension, dyslipidemia, type 2 diabetes, obesity, inflammation, non-alcoholic fatty liver …
hypertension, dyslipidemia, type 2 diabetes, obesity, inflammation, non-alcoholic fatty liver …
[HTML][HTML] Design, synthesis, docking and mechanistic studies of new thiazolyl/thiazolidinylpyrimidine-2, 4-dione antiproliferative agents
In this article, we display on the synthesis and biological evaluation of a new series of
thiazolylpyrimidine 3a-l and thiazolidinylpyrimidine derivatives 5a-e. The structures of the …
thiazolylpyrimidine 3a-l and thiazolidinylpyrimidine derivatives 5a-e. The structures of the …
Zein/phospholipid composite nanoparticles for successful delivery of gallic acid into ahscs: Influence of size, surface charge, and vitamin a coupling
SAA Radwan, WH El-Maadawy, C Yousry… - International journal …, 2020 - Taylor & Francis
Purpose Zein/phospholipid composite nanoparticles (CNPs) were developed as a delivery
platform for gallic acid (GA), a polyphenolic compound with reported preclinical antifibrotic …
platform for gallic acid (GA), a polyphenolic compound with reported preclinical antifibrotic …
Prospective therapeutics for intestinal and hepatic fibrosis
X Li, M Yu, Q Zhao, Y Yu - Bioengineering & translational …, 2023 - Wiley Online Library
Currently, there are no effective therapies for intestinal and hepatic fibrosis representing a
considerable unmet need. Breakthroughs in pathogenesis have accelerated the …
considerable unmet need. Breakthroughs in pathogenesis have accelerated the …
Recent advances in nanomedicine for the diagnosis and therapy of liver fibrosis
X Bai, G Su, S Zhai - Nanomaterials, 2020 - mdpi.com
Liver fibrosis, a reversible pathological process of inflammation and fiber deposition caused
by chronic liver injury and can cause severe health complications, including liver failure …
by chronic liver injury and can cause severe health complications, including liver failure …