Research into the causes of psychopathology has largely focused on two broad etiologic
factors: genetic vulnerability and environmental stressors. An important role for …

Adequate oxygen supply is essential for the human brain to meet its high energy demands.
Therefore, elaborate molecular and systemic mechanism are in place to enable adaptation …

The goal of the Brain Genomics Superstruct Project (GSP) is to enable large-scale
exploration of the links between brain function, behavior, and ultimately genetic variation. To …

Objectives: Biomarkers are defined as anatomical, biochemical or physiological traits that
are specific to certain disorders or syndromes. The objective of this paper is to summarise …

The epithelial Na+ channel (ENaC) and the acid-sensing ion channels (ASICs) form
subfamilies within the ENaC/degenerin family of Na+ channels. ENaC mediates …

Abstract Development of the pharmacology of Acid-Sensing Ion Channels (ASICs) has
become a key challenge to study their structure, their molecular and cellular functions and …

Acid-sensing ion channels (ASICs) are Na+-permeable ion channels activated by protons
and predominantly expressed in the nervous system. ASICs act as pH sensors leading to …

The pH in the different tissues and organs of our body is kept within tight limits. Local pH
changes occur, however, temporarily under physiological conditions, as for example in …

AIM To provide an overview of the current research in the functional neuroanatomy of panic
disorder. METHODS Panic disorder (PD) is a frequent psychiatric disease. Gorman et al …

Early-life adversities are associated with altered defensive responses. Here, we
demonstrate that the repeated cross-fostering (RCF) paradigm of early maternal separation …