Targeting ROS in cancer: rationale and strategies
C Glorieux, S Liu, D Trachootham… - Nature Reviews Drug …, 2024 - nature.com
Reactive oxygen species (ROS) in biological systems are transient but essential molecules
that are generated and eliminated by a complex set of delicately balanced molecular …
that are generated and eliminated by a complex set of delicately balanced molecular …
T cell dysfunction and therapeutic intervention in cancer
CC Zebley, D Zehn, S Gottschalk, H Chi - Nature Immunology, 2024 - nature.com
Recent advances in immunotherapy have affirmed the curative potential of T cell-based
approaches for treating relapsed and refractory cancers. However, the therapeutic efficacy is …
approaches for treating relapsed and refractory cancers. However, the therapeutic efficacy is …
Nutrients: Signal 4 in T cell immunity
JL Raynor, H Chi - Journal of Experimental Medicine, 2024 - rupress.org
T cells are integral in mediating adaptive immunity to infection, autoimmunity, and cancer.
Upon immune challenge, T cells exit from a quiescent state, followed by clonal expansion …
Upon immune challenge, T cells exit from a quiescent state, followed by clonal expansion …
Dietary elaidic acid boosts tumoral antigen presentation and cancer immunity via ACSL5
Y Lai, Y Gao, J Lin, F Liu, L Yang, J Zhou, Y Xue, Y Li… - Cell Metabolism, 2024 - cell.com
Immunomodulatory effects of long-chain fatty acids (LCFAs) and their activating enzyme,
acyl-coenzyme A (CoA) synthetase long-chain family (ACSL), in the tumor microenvironment …
acyl-coenzyme A (CoA) synthetase long-chain family (ACSL), in the tumor microenvironment …
[HTML][HTML] The impact of seasonal calving systems with varying pasture allowance on Cheddar cheese composition, nutritional quality, and ripening characteristics
The objective of this study was to examine the effect of stage of lactation (early, mid, and
late) and proportion of pasture in the cow's diet (high: GRS, medium: PMR, and no: TMR) on …
late) and proportion of pasture in the cow's diet (high: GRS, medium: PMR, and no: TMR) on …
[HTML][HTML] Principles and therapeutic applications of adaptive immunity
Adaptive immunity provides protection against infectious and malignant diseases. These
effects are mediated by lymphocytes that sense and respond with targeted precision to …
effects are mediated by lymphocytes that sense and respond with targeted precision to …
Focusing on CD8+ T-cell phenotypes: improving solid tumor therapy
Z Yao, Y Zeng, C Liu, H Jin, H Wang, Y Zhang… - Journal of Experimental …, 2024 - Springer
Vigorous CD8+ T cells play a crucial role in recognizing tumor cells and combating solid
tumors. How T cells efficiently recognize and target tumor antigens, and how they maintain …
tumors. How T cells efficiently recognize and target tumor antigens, and how they maintain …
The accessible chromatin landscape of lipopolysaccharide-induced systemic inflammatory response identifying epigenome signatures and transcription regulatory …
Lipopolysaccharide (LPS) can induce systemic inflammatory response (SIR) in animals.
Understanding the regulatory mechanism of SIR and therapies to ensure healthy growth is …
Understanding the regulatory mechanism of SIR and therapies to ensure healthy growth is …
Spatiotemporal metabolomic approaches to the cancer-immunity panorama: a methodological perspective
Y Xiao, Y Li, H Zhao - Molecular Cancer, 2024 - Springer
Metabolic reprogramming drives the development of an immunosuppressive tumor
microenvironment (TME) through various pathways, contributing to cancer progression and …
microenvironment (TME) through various pathways, contributing to cancer progression and …
Ketone bodies in cell physiology and cancer
G Giuliani, VD Longo - American Journal of Physiology-Cell …, 2024 - journals.physiology.org
Ketogenic diets (KDs), fasting, or prolonged physical activity elevate serum ketone bodies
(KBs) levels, providing an alternative fuel source for the brain and other organs. However …
(KBs) levels, providing an alternative fuel source for the brain and other organs. However …