Targeting ROS in cancer: rationale and strategies

C Glorieux, S Liu, D Trachootham… - Nature Reviews Drug …, 2024 - nature.com
Reactive oxygen species (ROS) in biological systems are transient but essential molecules
that are generated and eliminated by a complex set of delicately balanced molecular …

T cell dysfunction and therapeutic intervention in cancer

CC Zebley, D Zehn, S Gottschalk, H Chi - Nature Immunology, 2024 - nature.com
Recent advances in immunotherapy have affirmed the curative potential of T cell-based
approaches for treating relapsed and refractory cancers. However, the therapeutic efficacy is …

Nutrients: Signal 4 in T cell immunity

JL Raynor, H Chi - Journal of Experimental Medicine, 2024 - rupress.org
T cells are integral in mediating adaptive immunity to infection, autoimmunity, and cancer.
Upon immune challenge, T cells exit from a quiescent state, followed by clonal expansion …

Dietary elaidic acid boosts tumoral antigen presentation and cancer immunity via ACSL5

Y Lai, Y Gao, J Lin, F Liu, L Yang, J Zhou, Y Xue, Y Li… - Cell Metabolism, 2024 - cell.com
Immunomodulatory effects of long-chain fatty acids (LCFAs) and their activating enzyme,
acyl-coenzyme A (CoA) synthetase long-chain family (ACSL), in the tumor microenvironment …

[HTML][HTML] The impact of seasonal calving systems with varying pasture allowance on Cheddar cheese composition, nutritional quality, and ripening characteristics

M Timlin, A Brodkorb, N Harbourne… - Journal of Dairy …, 2024 - Elsevier
The objective of this study was to examine the effect of stage of lactation (early, mid, and
late) and proportion of pasture in the cow's diet (high: GRS, medium: PMR, and no: TMR) on …

[HTML][HTML] Principles and therapeutic applications of adaptive immunity

H Chi, M Pepper, PG Thomas - Cell, 2024 - cell.com
Adaptive immunity provides protection against infectious and malignant diseases. These
effects are mediated by lymphocytes that sense and respond with targeted precision to …

Focusing on CD8+ T-cell phenotypes: improving solid tumor therapy

Z Yao, Y Zeng, C Liu, H Jin, H Wang, Y Zhang… - Journal of Experimental …, 2024 - Springer
Vigorous CD8+ T cells play a crucial role in recognizing tumor cells and combating solid
tumors. How T cells efficiently recognize and target tumor antigens, and how they maintain …

The accessible chromatin landscape of lipopolysaccharide-induced systemic inflammatory response identifying epigenome signatures and transcription regulatory …

Z Lv, H Fan, M Gao, X Zhang, G Li, Y Fan, Z Ning… - International Journal of …, 2024 - Elsevier
Lipopolysaccharide (LPS) can induce systemic inflammatory response (SIR) in animals.
Understanding the regulatory mechanism of SIR and therapies to ensure healthy growth is …

Spatiotemporal metabolomic approaches to the cancer-immunity panorama: a methodological perspective

Y Xiao, Y Li, H Zhao - Molecular Cancer, 2024 - Springer
Metabolic reprogramming drives the development of an immunosuppressive tumor
microenvironment (TME) through various pathways, contributing to cancer progression and …

Ketone bodies in cell physiology and cancer

G Giuliani, VD Longo - American Journal of Physiology-Cell …, 2024 - journals.physiology.org
Ketogenic diets (KDs), fasting, or prolonged physical activity elevate serum ketone bodies
(KBs) levels, providing an alternative fuel source for the brain and other organs. However …