In cardiomyocytes, invaginations of the sarcolemmal membrane called t-tubules are critically
important for triggering contraction by excitation-contraction (EC) coupling. These structures …

Abstract Calcium (Ca 2+) plays a central role in cardiomyocyte excitation-contraction
coupling. To ensure an optimal electrical impulse propagation and cardiac contraction, Ca …

Contraction of cardiomyocytes is dependent on sub-cellular structures called dyads, where
invaginations of the surface membrane (t-tubules) form functional junctions with the …

Aims Exercise increases arrhythmia risk and cardiomyopathy progression in arrhythmogenic
right ventricular cardiomyopathy (ARVC) patients, but the mechanisms remain unknown. We …

Regulation of intracellular calcium is a critical component of cardiac electrophysiology and
excitation-contraction coupling. The calcium spark, the fundamental element of the …

The prospective use of human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-
CM) for cardiac regenerative medicine strongly depends on the electro-mechanical …

BIN1 (amphyphysin-II) is a structural protein involved in T-tubule (TT) formation and
phosphatidylinositol-4, 5-bisphosphate (PIP2) is responsible for localization of BIN1 to …

Aims Biological sex has fundamental effects on mammalian heart physiology and
pathogenesis. While it has been established that female sex is a protective factor against …

The goal of this work was to investigate the role of t-tubule (TT) remodeling in abnormal
Ca2+ cycling in ventricular myocytes of failing dog hearts. Heart failure (HF) was induced …

Abstract α2-Adrenoceptors (α2-AR) found in the cardiomyocyte's sarcolemma represent a
very important negative feedback for control of myocardial contractility by endogenous …