The chemokine receptor CXCR2 and its ligands are implicated in the progression of tumours
and various inflammatory diseases. Activation of the CXCLs/CXCR2 axis activates multiple …

Recent data have expanded the concept that inflammation is a critical component of tumour
progression. Many cancers arise from sites of infection, chronic irritation and inflammation. It …

Autophagy is a mechanism by which starving cells can control their energy requirements
and metabolic states, thus facilitating the survival of cells in stressful environments, in …

The use of various transgenic mouse models and analysis of human tumour biopsies has
shown that bone marrow-derived myeloid cells, such as macrophages, neutrophils …

Myofibroblasts are a unique group of smooth-muscle-like fibroblasts that have a similar
appearance and function regardless of their tissue of residence. Through the secretion of …

CXCL5 (epithelial neutrophil‐activating peptide‐78) is a member of a proangiogenic
subgroup of the CXC‐type chemokine family of small, secreted proteins. Recently, evidence …

Mesenchymal stem cells (MSCs) are promising tools for the treatment of diseases such as
infarcted myocardia and strokes because of their ability to promote endogenous …

Tumor cells stimulate the formation of stroma that secretes various mediators pivotal for
tumor growth, including growth factors, cytokines, and proteases. However, little is known …

Chemokines, or chemotactic cytokines, and their receptors have been discovered as
essential and selective mediators in leukocyte migration to inflammatory sites and to …

A variety of factors have been identified that regulate angiogenesis, including the CXC
chemokine family. The CXC chemokines are a unique family of cytokines for their ability to …