WEE1 kinase plays a crucial role in the G2–M cell-cycle checkpoint arrest for DNA repair
before mitotic entry. Normal cells repair damaged DNA during G1 arrest; however, cancer …

The size and extent of folding of the mammalian cerebral cortex are important factors that
influence a species' cognitive abilities and sensorimotor skills. Studies in various animal …

Alternative splicing is prevalent in the mammalian brain. To interrogate the functional role of
alternative splicing in neural development, we analyzed purified neural progenitor cells …

Filamin A (FlnA) has been associated with actin as cytoskeleton regulator. Recently its role
in the cell has come under scrutiny for FlnA's involvement in cancer development. FlnA was …

Filamin A (FLNa) is an actin-binding protein, which participates in the formation of the
cytoskeleton, anchors a variety of proteins in the cytoskeleton and regulates cell adhesion …

Neurodevelopmental disorders with periventricular nodular heterotopia (PNH) are
etiologically heterogeneous, and their genetic causes remain in many cases unknown. Here …

The morphology of the adult brain is the result of a delicate balance between neural
progenitor proliferation and the initiation of neurogenesis in the embryonic period. Here we …

Background Trauma-associated peripheral nerve injury is a widespread clinical problem
causing sensory and motor disabilities. Schwann cells (SCs) contribute to nerve …

Abstract Filamin-A (FLNA), also called actin-binding protein 280 (ABP-280), was originally
identified as a non-muscle actin binding protein, which organizes filamentous actin into …

Corticogenesis is an intricate process controlled temporally and spatially by many intrinsic
and extrinsic factors. Alterations during this important process can lead to severe cortical …