Multiple lines of evidence place STAT3 at a central node in the development, progression,
and maintenance of many human tumors, and STAT3 has been validated as an anti-cancer …

Signal transducer and activator of transcription (STAT) proteins are latent transcription
factors that reside in the cytoplasm of several types of cells. In canonical signaling, upon …

Cancer is a major public health problem and the second leading cause of mortality around
the world. Although continuous advances in the science of oncology and cancer research …

Background Increasing evidence indicates that obesity is associated with tumor
development and progression. Leptin is an adipocyte-related hormone with a key role in …

Obesity is increasingly becoming a global epidemic of concern and is considered a risk
factor for several endocrine-related cancers. Moreover, obesity is associated with cancer …

Abstract Non-Small-Cell Lung Cancer (NSCLC) is considered one of the most frequently
diagnosed cancers and the leading cause of cancer-related deaths worldwide. Despite the …

Abstract Protein Kinase A (PKA) is a well known member of the serine-threonin protein
kinase superfamily. PKA, also known as cAMP-dependent protein kinase, is a multi-unit …

Obesity increases the risk of developing multiple myeloma (MM). Adiponectin is a cytokine
produced by adipocytes, but paradoxically decreased in obesity, that has been implicated in …

Introduction Adipokines are known to play a relevant role in a number of cancer related
molecular pathways. Adiponectin is a major adipokine with anti-inflammatory and beneficial …

Abstract Members of microRNA-200 (miRNA-200) family have a regulatory role in epithelial
to mesenchymal transition (EMT) by suppressing Zeb1 and Zeb2 expression. Consistent …