Retrotransposons have generated about 40% of the human genome. This review examines
the strategies the cell has evolved to coexist with these genomic “parasites”, focussing on …

Transposable elements (TEs) or “jumping genes” historically have been disparaged as a
class of “junk DNA” in mammalian genomes (1, 2). The advent of whole genome DNA …

Only a small proportion of patients with cancer show lasting responses to immune
checkpoint blockade (ICB)-based monotherapies. The RNA-editing enzyme ADAR1 is an …

Mice deficient for SIRT6 exhibit a severely shortened lifespan, growth retardation, and highly
elevated LINE1 (L1) activity. Here we report that SIRT6-deficient cells and tissues …

Recent advances in single-cell technologies have led to the discovery of thousands of brain
cell types; however, our understanding of the gene regulatory programs in these cell types is …

After fertilization, to initiate development, gametes are reprogramed to become totipotent.
Approximately half of the mammalian genome consists of repetitive elements, including …

Transposable elements (TEs) were discovered by Barbara McClintock in maize and have
since been found to be ubiquitous in all living organisms. Transposition is mutagenic and …

Abstract Long Interspersed Nuclear Elements-1s (L1s) are transposable elements that
constitute most of the genome's transcriptional output yet have still largely unknown …

Mouse embryos acquire global DNA methylation of their genome during implantation.
However the exact roles of DNA methyltransferases (DNMTs) in embryos have not been …

In eukaryotes, repetitive DNA sequences are transcriptionally silenced through histone H3
lysine 9 trimethylation (H3K9me3). Loss of silencing of the repeat elements leads to genome …