The present invention relates to chirally controlled oligonucleotides, chirally controlled
oligonucleotide compositions, and the method of making and using the same. The invention …

The present application, among other things, provides technologies, eg, reagents, methods,
etc. for preparing oligonucleotides comprising phosphorothiotriesters linkages, eg …

US9695211B2 - Method for the synthesis of phosphorus atom modified nucleic acids - Google
Patents US9695211B2 - Method for the synthesis of phosphorus atom modified nucleic acids …

Solution The present invention relates to an adjuvant which com prises oligonucleotides
which comprise two to four sequences each represented by 5'-X, CpG X2-3'and has a length …

Abstract wherein each nucleic acid at 3′ end and 5′ end of the oligonucleotide is S type
nucleic acid connected by phosphorothioate linkage, and wherein the oligonucleotide …

3,687,808 A 8, 1972 Merigan et al. 3,745,162 A 7/1973 Helsley 4,022,791 A 5/1977 Welch,
Jr. 4,113,869 A 9, 1978 Gardner 4.415, 732 A 11, 1983 Caruthers et al. 4,458,066 A 7, 1984 …

2017-06-14 Assigned to ONTORII, INC. reassignment ONTORII, INC. ASSIGNMENT OF
ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: ZLATEV, IVAN …

Tulic et al Amb a 1-immunostimulatory oligodeoxynucleotide conjugate immunotherapy
decreases the nasal inflammatory response J Allergy Olin Immunol pp. 235-241.* IEE et al …

CO7H 1/00(2006. 01) CO7H 23/00(2006. 01) CO7B 53/00(2006. 01) CO7H 19/11(2006. 01)
C07H 19/213(2006. 01) CO7H 21/04(2006. 01) CO7D 405/04(2006. 01) C07D …

2012-09-25 First worldwide family litigation filed litigation Critical https://patents. darts-ip.
com/? family= 43429503&utm_source= google_patent&utm_medium …