Metastatic spine disease is a heterogeneous clinical condition commonly requiring surgical
intervention. Despite this heterogeneity, all cases share the common theme of altered tumor …

Sodium dichloroacetate (DCA) is an investigational medicinal product which has a potential
anticancer preparation as a metabolic regulator in cancer cells' mitochondria. Inhibition of …

Rarely has a chemical elicited as much controversy as dichloroacetate (DCA). DCA was
initially considered a dangerous toxic industrial waste product, then a potential treatment for …

Background: The efficacy of antimetabolic therapy of malignant neoplasms could not be
explained solely by the direct mechanisms of action of such energy metabolism inhibitors as …

The use of inhibitors of energy metabolism of malignant cells is a new promising trend in the
treatment of cancer patients, based on one of the unique features of the malignant cell …

Background Sodium dichloroacetate (DCA) is an agent with anticancer properties against
solid tumors. DCA also seems to have antileukemic activity. In order to affirm it we …

CHAPTER 1: BASIC CONCEPTS CHAPTER 2: METABOLIC FEATURES OF CANCERS:
THE ICEBERG CHAPTER 3: WHY DOES METABOLISM CHANGE IN CANCER? CHAPTER …

With most of the cancer-related deaths arising from the metastatic spread, it is of great
biomedical importance to develop new therapeutic approaches against metastasis. In this …

Bueno, pues por fin estamos aquí. Parece que fue ayer cuando arranqué mis andaduras
con el Doctorado, sin saber muy bien dónde me metía (¿ y quién lo sabe?). Parecía que …

Bioenergetics and cancer metabolism are reviewed, illustrating the mechanisms and
functional impact of the known oncogenic metabolic programs. Oncogenic mutations and …