Alkaloids mimicking the structures of monosaccharides are now believed to be widespread
in plants and microorganisms, and these sugar mimics inhibit glycosidases because of a …

Covering: up to April 2014 The development of drugs with broad-spectrum antiviral activities
is a long pursued goal in drug discovery. It has been shown that blocking co-opted host …

Using a pulse-chase approach combined with immunoprecipitation, we showed that newly
synthesized influenza virus hemagglutinin (HA) and vesicular stomatitis virus G protein …

Kifunensine, produced by the actinomycete Kitasatosporia kifunense 9482, is an alkaloid
that corresponds to a cyclic oxamide derivative of 1-amino mannojirimycin. This compound …

INTRODUCTION In eukaryotic cells, a large fraction of the proteins syn-thesized acquire
oneor more N-linked oligosaccharides. These are added as core oligosaccharide units to …

Previous studies have suggested that α-glucosidase inhibitors such as castanospermine
and deoxynojirimycin inhibit dengue virus type 1 infection by disrupting the folding of the …

Phytochemicals are constitutive metabolites that enable plants to overcome temporary or
continuous threats integral to their environment, while also controlling essential functions of …

Castanospermine (1, 6, 7, 8-tetrahydroxyoctahydroindolizine) is a plant alkaloid that
modifies glycosylation by inhibiting alpha-glucosidase I. Castanospermine is shown to …

Among the common types of glycoproteins that are found in eukaryotic cells, both as cell
surface proteins and as secreted proteins, are those having N-linked or asparagine-linked …

Australine [1], a tetrahydroxy pyrrolizidine alkaloid with a unique sub-stitution pattern, has
been isolated from seeds of Castanospermum australeand shown to be a po-tent and …