Severe injuries and diseases of bone tissue caused by congenital disorder, extrinsic trauma,
infection, and osteosarcoma resection face significant challenges for complete recovery. The …

Cryogels are a class of macroporous, interconnective hydrogels polymerized at sub-zero
temperatures forming mechanically robust, elastic networks. In this review, latest advances …

Bone regeneration is a complicated physiological process regulated by several growth
factors. In particular, vascular endothelial growth factor (VEGF) and bone morphogenetic …

Objectives Large bone defects are a common, debilitating clinical condition that have
substantial global health and economic burden. Bone tissue engineering technology has …

Critical-sized bone defects and articular cartilage injuries resulting from trauma,
osteonecrosis, or age-related degeneration can be often non-healed by physiological …

Abstract Bone morphogenetic protein 4 (BMP4) is emerging as a promising cytokine for
regenerative medicine and tissue engineering. BMP4 has been shown to promote the …

Silicon nitride (SiN [Si3N4]) is a promising bioceramic for use in a wide variety of orthopedic
applications. Over the past decades, it has been mainly used in industrial applications, such …

Ovarian function declines significantly as females enter middle-age, but the mechanisms
underlying this decline remain unclear. Here, we utilize whole-organ imaging to observe a …

Background Randall's plaques (RP) are identified as anchored sites for kidney calcium
oxalate stones, but the mechanism remains unclear. Given the importance of osteogenic-like …

Calcification is a process of accumulation of calcium in tissues and deposition of calcium
salts by the crystallization of PO43− and ionized calcium (Ca2+). It is a crucial process in the …