Keratins are the major structural proteins of the vertebrate epidermis and its appendages,
constituting up to 85% of a fully differentiated keratinocyte. Together with actin …

Publisher Summary This chapter focuses on intermediate-filament (IF)-protein family and
describes the role intermediate filaments play within cells and tissues. IFs are composed of …

The nuclear lamina is a fundamental component involved in the assembly of the nuclear
envelope and higher order chromosomal structures in eukaryotes. In mammals, it is …

The muscle-specific intermediate filament protein, desmin, is one of the earliest myogenic
markers whose functional role during myogenic commitment and differentiation is unknown …

Mechanical interactions between desmin and Z-disks, costameres, and nuclei were
measured during passive deformation of single muscle cells. Image processing and …

Human SW-13 cells express the intermediate filament protein vimentin in a mosaic pattern
(Hedberg, KK and Chen, LB (1986). Exp. Cell Res. 163, 509-517). We have isolated SW-13 …

The small heat shock protein αβ-crystallin interacts with intermediate filament proteins.
Using a co-sedimentation assay, we showed that in vitro binding of αβ-crystallin to …

The adult mammalian cochlea receives dual afferent innervation: the inner sensory hair cells
are innervated exclusively by type I spiral ganglion neurons (SGN), whereas the sensory …

Neurotrophic factors are naturally-occurring proteins which are essential for neuronal
survival and differentiation during development and for the maintenance of normal neuronal …

Previously thought to reside exclusively in the cytoplasm, the cytoskeletal protein keratin 17
(K17) has been recently identified inside the nucleus of tumor epithelial cells with a direct …