Adenosine deaminase acting on RNA (ADAR) catalyzes the posttranscriptional conversion
of adenosine to inosine in double‐stranded RNA (dsRNA), which can lead to the creation of …

Specialized receptors that recognize molecular patterns such as double stranded RNA
duplexes—indicative of viral replication—are potent triggers of the innate immune system …

Type I and III interferons (IFN-I/λ) are important antiviral mediators against SARS-CoV-2
infection. Here, we demonstrate that plasmacytoid dendritic cells (pDC) are the predominant …

Abstract VirHostNet release 2.0 (http://virhostnet. prabi. fr) is a knowledgebase dedicated to
the network-based exploration of virus–host protein–protein interactions. Since the previous …

C6 deamination of adenosine (A) to inosine (I) in double-stranded RNA (dsRNA) is
catalyzed by a family of enzymes known as ADARs (adenosine deaminases acting on RNA) …

Influenza A virus is one of the major human pathogens. Despite numerous efforts to produce
absolutely effective anti-influenza drugs or vaccines, no such agent has been developed yet …

The molecular basis for the diversity across influenza strains is poorly understood. To gain
insight into this question, we mutagenized the viral genome and sequenced recoverable …

RNA viruses are unique in their evolutionary capacity, exhibiting high mutation rates and
frequent recombination. They rapidly adapt to environmental changes, such as shifts in …

The non-structural protein 1 of influenza virus (NS1) is a relatively small polypeptide with an
outstanding number of ascribed functions. NS1 is the main viral antagonist of the innate …

Most viruses express one or several proteins that counter the antiviral defences of the host
cell. This is the task of non-structural protein NS1 in influenza viruses. Absent in the viral …