Abstract Attenuated Total Reflection Fourier Transform Infrared (ATR-FTIR) spectroscopy is
a label-free, non-destructive technique that can be applied to a vast range of biological …

Real‐time monitoring of bioprocesses by the integration of analytics at critical unit
operations is one of the paramount necessities for quality by design manufacturing and real …

Process analytical technology (PAT) for the manufacture of monoclonal antibodies (mAbs) is
defined by an integrated set of advanced and automated methods that analyze the …

Inclusion bodies (IBs) often emerge upon overexpression of recombinant proteins in E. coli.
From IBs, refolding is necessary to generate the native protein that can be further purified to …

As competition in the biopharmaceutical market gets keener due to the market entry of
biosimilars, process analytical technologies (PATs) play an important role for process …

Integrated continuous manufacturing is entering the biopharmaceutical industry. The main
drivers range from improved economics, manufacturing flexibility, and more consistent …

Real-time monitoring of biopharmaceutical reactors is becoming increasingly important as
the processes become more complex. During the continuous manufacturing of monoclonal …

Continuous production delivers higher productivity and better quality than traditional batch-
wise approaches. It intensifies production lowering capital cost and enables better control …

In recent years process modelling has become an established method which generates
digital twins of manufacturing plant operation with the aid of numerically solved process …

Continuous integrated bioprocessing has elicited considerable interest from the biopharma
industry for the many purported benefits it promises. Today many major biopharma …