Colorectal cancer (CRC) is a leading cause of cancer deaths worldwide. It results from an
accumulation of genetic and epigenetic changes in colon epithelial cells, which transforms …

Epigenetic modification refers to heritable changes in gene function that cannot be
explained by alterations in the DNA sequence. The current literature clearly demonstrates …

Objective Colorectal cancer is typically classified into proximal colon, distal colon and rectal
cancer. Tumour genetic and epigenetic features differ by tumour location. Considering a …

Physical activity is a strong stimulus influencing the overall physiology of the human body.
Exercises lead to biochemical changes in various tissues and exert an impact on gene …

Purpose: Alterations in the RAS-RAF-MAP2K (MEK)-MAPK signaling pathway are major
drivers in colorectal carcinogenesis. In colorectal cancer, BRAF mutation is associated with …

In the 1980s, epidemiological and molecular data suggested that cancers arising at different
subsites may be biologically disparate, implying different cancer aetiologies or evolutions …

The term 'field effect'(also known as field defect, field cancerization, or field carcinogenesis)
has been used to describe a field of cellular and molecular alteration, which predisposes to …

Importance Aspirin use reduces the risk of colorectal carcinoma. Experimental evidence
implicates a role of RAF kinases in up-regulation of prostaglandin-endoperoxide synthase 2 …

Molecular pathology diagnostics to subclassify diseases based on pathogenesis are
increasingly common in clinical translational medicine. Molecular pathological epidemiology …

Abstract Purpose of Review In this review, we describe molecular pathological epidemiology
(MPE) studies from around the world that have studied diet and/or lifestyle factors in relation …