Particle design via spherical agglomeration is a size enlargement technique used in various
bulk and fine chemical industries, with recent interest extending into pharmaceuticals, in …

Direct compaction (DC) is the preferred method for tablet production. However, only a
minority of the active pharmaceutical ingredients (APIs) can be truly manufactured into …

The aim of present work was to produce fine elongated crystals of salbutamol sulphate (SS)
by sonocrystallization for pulmonary delivery and compare with micronized and spray dried …

Drug substance purification by crystallization is a key interface in going from drug substance
synthesis to final formulation and can often be a bottleneck in process efficiency. There has …

The aim of this study was to prepare spherical agglomerates of lactose and to evaluate their
physicochemical properties, flow properties, particle friability and compaction properties …

This paper deals with the development of a method for spherical crystallization of benzoic
acid. Benzoic acid is dissolved in ethanol, water is used as anti-solvent and chloroform is …

Celecoxib exhibits poor flow properties and compressibility. Spherical crystallization of
celecoxib was carried out using the solvent change method. An acetone: dichloromethane …

Spherical crystallization of drugs is the process of obtaining larger particles by
agglomeration during crystallization. The most common techniques used to obtain such …

Spherical crystallization enables the direct preparation of crystal agglomerates of active
pharmaceutical ingredients (APIs) with improved crystal handling properties. The continuous …

Objectives The main aim of this review was to develop a critical discussion of the key role
ultrasound (US) can play on the production of active pharmaceutical ingredients (APIs) by …