Cryptococcus neoformans and Cryptococcus gattii are the two etiologic agents of
cryptococcosis. They belong to the phylum Basidiomycota and can be readily distinguished …

This review is an attempt to retrace the chronicle that starts from the discovery of the role of
nickel as the essential metal ion in urease for the enzymatic catalysis of urea, a key step in …

Among fungal pathogens, Cryptococcus neoformans has gained great importance among
the scientific community of several reasons. This fungus is the causative agent of …

Cryptococcus neoformans is a pathogenic basidiomycetous yeast responsible for more than
600,000 deaths each year. It occurs as two serotypes (A and D) representing two varieties …

Abstract Urease (urea amidohydrolase, EC 3.5. 1.5) is a nickel-containing enzyme produced
by plants, fungi, and bacteria that catalyzes the hydrolysis of urea into ammonia and …

Cryptococcus neoformans is an encapsulated fungal pathogen that causes infection in
immunocompromised individuals such as HIV patients, organ transplant patients …

The importance of nickel enzymes, where nickel serves as an essential cofactor, in Archaea,
bacteria, plants, and primitive eukaryotes, is well documented. 1 Despite the fact that no …

Cryptococcus neoformans produces vesicles containing its major virulence factor, the
capsular polysaccharide glucuronoxylomannan (GXM). These vesicles cross the cell wall to …

There has recently been an explosion of interest in the analysis of breath constituents as a
way of monitoring inflammation and oxidative stress in the lungs. Here we review the use of …

Cryptococcus neoformans is generally considered to be an opportunistic fungal pathogen
because of its tendency to infect immunocompromised individuals, particularly those …