Broadly neutralizing antibodies against HIV-1 and concepts for application
H Gruell, P Schommers - Current Opinion in Virology, 2022 - Elsevier
Highlights•Broadly neutralizing antibodies are promising for HIV-1 prevention and
therapy.•Newly identified bNAbs reveal novel epitopes and binding modes.•Effective …
therapy.•Newly identified bNAbs reveal novel epitopes and binding modes.•Effective …
Preventing perinatal HIV acquisition; current gaps and future perspectives
B Cockbain, S Fidler, H Lyall - Current Opinion in HIV and AIDS, 2024 - journals.lww.com
Emerging clinical studies should prioritize pregnant/lactating people and infants to ensure
such therapies are well tolerated and efficacious. Alongside therapeutic innovation …
such therapies are well tolerated and efficacious. Alongside therapeutic innovation …
Immunotherapeutic approaches to HIV cure and remission
Although progress with newer cure strategies may be encouraging, challenges remain and it
is essential to achieve a high threshold of safety and effectiveness in the era of safe and …
is essential to achieve a high threshold of safety and effectiveness in the era of safe and …
Evaluation of HIV-1 reservoir size and broadly neutralizing antibody susceptibility in acute antiretroviral therapy-treated individuals
Objective: Persistence of the viral reservoir is the main barrier to curing HIV. Initiation of ART
during acute HIV infection can limit the size and diversity of the reservoir. In depth …
during acute HIV infection can limit the size and diversity of the reservoir. In depth …
Neutralizing the threat: harnessing broadly neutralizing antibodies against HIV-1 for treatment and prevention
JC Becerra, L Hitchcock, K Vu, JS Gach - Microbial Cell, 2024 - pmc.ncbi.nlm.nih.gov
Broadly neutralizing antibodies (bnAbs) targeting the human immunodeficiency virus-1 (HIV-
1) have played a crucial role in elucidating and characterizing neutralization-sensitive sites …
1) have played a crucial role in elucidating and characterizing neutralization-sensitive sites …
Susceptibility to 3BNC117 and 10-1074 in ART suppressed chronically infected persons
P Tebas, K Lynn, L Azzoni, G Cocchella, E Papasavvas… - AIDS, 2023 - journals.lww.com
Objective: The aim of this study was to assess the susceptibility of HIV to two HIV
monoclonal antibodies (bnAbs), 3BNC117 and 10-1074, in individuals with chronically …
monoclonal antibodies (bnAbs), 3BNC117 and 10-1074, in individuals with chronically …
Susceptibility to lenacapavir, fostemsavir and broadly neutralizing antibodies in French primary HIV‐1 infected patients in 2020–2023
ML Chaix, L Terracol, ML Nere, K Stefic… - Journal of Medical …, 2024 - Wiley Online Library
Abstract Surveillance studies of Transmitted Drug Resistance (TDR) are crucial in tracking
the evolution of HIV epidemiology. Our aim was to investigate TDR to nucleoside reverse …
the evolution of HIV epidemiology. Our aim was to investigate TDR to nucleoside reverse …
[HTML][HTML] To prescreen or not to prescreen for broadly neutralizing antibody sensitivity in HIV cure-related trials
The use of broadly neutralizing antibodies (bNAbs) as a cure-related research strategy for
human immunodeficiency virus (HIV) has gained attention from the scientific community …
human immunodeficiency virus (HIV) has gained attention from the scientific community …
HIV-1 envelope diversity and sensitivity to broadly neutralizing antibodies across stages of acute HIV-1 infection
LA VanderVeen, L Selzer, B Moldt, A Parvangada, J Li… - AIDS, 2024 - journals.lww.com
We studied the relationship between viral diversity and susceptibility to broadly neutralizing
antibodies (bNAbs) in longitudinal plasma and peripheral blood mononuclear cells from 89 …
antibodies (bNAbs) in longitudinal plasma and peripheral blood mononuclear cells from 89 …
[PDF][PDF] Journal of Virus Eradication
The use of broadly neutralizing antibodies (bNAbs) as a cure-related research strategy for
human immunodeficiency virus (HIV) has gained attention from the scientific community …
human immunodeficiency virus (HIV) has gained attention from the scientific community …