Pharmacology of adenosine receptors: the state of the art
Adenosine is a ubiquitous endogenous autacoid whose effects are triggered through the
enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Due to the rapid …
enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Due to the rapid …
[HTML][HTML] Cardiac transmembrane ion channels and action potentials: cellular physiology and arrhythmogenic behavior
Cardiac arrhythmias are among the leading causes of mortality. They often arise from
alterations in the electrophysiological properties of cardiac cells and their underlying ionic …
alterations in the electrophysiological properties of cardiac cells and their underlying ionic …
2019 ESC guidelines for the management of patients with supraventricular tachycardia the task force for the management of patients with supraventricular tachycardia …
J Brugada, DG Katritsis, E Arbelo, F Arribas… - European heart …, 2020 - academic.oup.com
Supraventricular arrhythmias are common and patients are often symptomatic, requiring
management with drugs and electrophysiological procedures. The ESC published …
management with drugs and electrophysiological procedures. The ESC published …
Calcium signaling and cardiac arrhythmias
There has been a significant progress in our understanding of the molecular mechanisms by
which calcium (Ca2+) ions mediate various types of cardiac arrhythmias. A growing list of …
which calcium (Ca2+) ions mediate various types of cardiac arrhythmias. A growing list of …
Modernized classification of cardiac antiarrhythmic drugs
M Lei, L Wu, DA Terrar, CLH Huang - Circulation, 2018 - Am Heart Assoc
Background: Among his major cardiac electrophysiological contributions, Miles Vaughan
Williams (1918–2016) provided a classification of antiarrhythmic drugs that remains central …
Williams (1918–2016) provided a classification of antiarrhythmic drugs that remains central …
Translational challenges in atrial fibrillation
Atrial fibrillation (AF) is the most common sustained heart rhythm disorder and is associated
with substantial morbidity and mortality. Current treatment options for AF have significant …
with substantial morbidity and mortality. Current treatment options for AF have significant …
Redundant and diverse intranodal pacemakers and conduction pathways protect the human sinoatrial node from failure
The human sinoatrial node (SAN) efficiently maintains heart rhythm even under adverse
conditions. However, the specific mechanisms involved in the human SAN's ability to …
conditions. However, the specific mechanisms involved in the human SAN's ability to …
Fibrosis and atrial fibrillation: computerized and optical mapping: a view into the human atria at submillimeter resolution
Recent studies strongly suggest that the majority of atrial fibrillation (AF) patients with
diagnosed or subclinical cardiac diseases have established or even pre-existing fibrotic …
diagnosed or subclinical cardiac diseases have established or even pre-existing fibrotic …
Imaging assessment of the right atrium: anatomy and function
The right atrium (RA) is the cardiac chamber that has been least well studied. Due to recent
advances in interventional cardiology, the need for greater understanding of the RA …
advances in interventional cardiology, the need for greater understanding of the RA …
Pharmacologic approach to sinoatrial node dysfunction
P Mesirca, VV Fedorov, TJ Hund… - Annual review of …, 2021 - annualreviews.org
The spontaneous activity of the sinoatrial node initiates the heartbeat. Sino-atrial node
dysfunction (SND) and sick sinoatrial (sick sinus) syndrome are caused by the heart's …
dysfunction (SND) and sick sinoatrial (sick sinus) syndrome are caused by the heart's …