Type I interferons in anticancer immunity
Type I interferons (IFNs) are known for their key role in antiviral immune responses. In this
Review, we discuss accumulating evidence indicating that type I IFNs produced by …
Review, we discuss accumulating evidence indicating that type I IFNs produced by …
Cytokines and costimulation in acute graft-versus-host disease
GR Hill, M Koyama - Blood, The Journal of the American …, 2020 - ashpublications.org
Allogeneic hematopoietic stem cell transplantation (alloSCT) is an important curative
therapy for high-risk hematological malignancies, but the development of severe and/or …
therapy for high-risk hematological malignancies, but the development of severe and/or …
A high OXPHOS CD8 T cell subset is predictive of immunotherapy resistance in melanoma patients
Immune checkpoint inhibitor (ICI) therapy continues to revolutionize melanoma treatment,
but only a subset of patients respond. Major efforts are underway to develop minimally …
but only a subset of patients respond. Major efforts are underway to develop minimally …
Indoles derived from intestinal microbiota act via type I interferon signaling to limit graft-versus-host disease
A Swimm, CR Giver, Z DeFilipp… - Blood, The Journal …, 2018 - ashpublications.org
The intestinal microbiota in allogeneic bone marrow transplant (allo-BMT) recipients
modulates graft-versus-host disease (GVHD), a systemic inflammatory state initiated by …
modulates graft-versus-host disease (GVHD), a systemic inflammatory state initiated by …
Cytokines in graft-versus-host disease
AS Henden, GR Hill - The Journal of Immunology, 2015 - journals.aai.org
Graft-versus-host disease (GVHD) is a complication of allogeneic bone marrow
transplantation whereby transplanted naive and marrow-derived T cells damage recipient …
transplantation whereby transplanted naive and marrow-derived T cells damage recipient …
RIG-I/MAVS and STING signaling promote gut integrity during irradiation-and immune-mediated tissue injury
JC Fischer, M Bscheider, G Eisenkolb, CC Lin… - Science translational …, 2017 - science.org
The molecular pathways that regulate the tissue repair function of type I interferon (IFN-I)
during acute tissue damage are poorly understood. We describe a protective role for IFN-I …
during acute tissue damage are poorly understood. We describe a protective role for IFN-I …
ST2 blockade reduces sST2-producing T cells while maintaining protective mST2-expressing T cells during graft-versus-host disease
Graft-versus-host disease (GVHD) remains a devastating complication after allogeneic
hematopoietic cell transplantation (HCT). We previously identified high plasma soluble …
hematopoietic cell transplantation (HCT). We previously identified high plasma soluble …
Harnessing the immune system in acute myeloid leukaemia
Acute myeloid leukaemia (AML) is an aggressive blood cancer caused by the proliferation of
immature myeloid cells. The genetic abnormalities underlying AML affect signal transduction …
immature myeloid cells. The genetic abnormalities underlying AML affect signal transduction …
Identification and expansion of highly suppressive CD8+FoxP3+ regulatory T cells after experimental allogeneic bone marrow transplantation
RJ Robb, KE Lineburg, RD Kuns… - Blood, The Journal …, 2012 - ashpublications.org
FoxP3+ confers suppressive properties and is confined to regulatory T cells (Treg) that
potently inhibit autoreactive immune responses. In the transplant setting, natural CD4+ Treg …
potently inhibit autoreactive immune responses. In the transplant setting, natural CD4+ Treg …
The yin and yang of type I IFNs in cancer promotion and immune activation
M Musella, C Galassi, N Manduca, A Sistigu - Biology, 2021 - mdpi.com
Simple Summary The crucial immune stimulatory functions exerted by Type I Interferons
(IFNs) in cancer settings have been not only widely demonstrated during the last fifty years …
(IFNs) in cancer settings have been not only widely demonstrated during the last fifty years …