The majority of pregnancy loss in ruminants occurs during the first three weeks after
conception, particularly during the period of conceptus elongation that occurs prior to …

During the past 50 years, the fertility of high-producing lactating dairy cows has decreased,
associated with intensive selection for increased milk production. The physiological and …

Embryo implantation into receptive endometrium requires synergistic endometrial-blastocyst
interactions within the uterine cavity and is essential for establishing pregnancy. We …

Microvesicles and exosomes are nanoparticles released from cells and can contain small
RNAs, mRNA and proteins that affect cells at distant sites. In sheep, endogenous beta …

This review integrates established and new information on the role of progesterone,
interferon tau (IFNT), and prostaglandins in uterine biology of ruminants. Establishment of …

In cattle, elevated concentrations of circulating progesterone (P4) in the immediate
postconception period are associated with advanced conceptus development, while low P4 …

This study sought to determine the earliest response of the bovine uterine endometrium to
the presence of the conceptus at key developmental stages of early pregnancy. There were …

A major unresolved issue is how the uterus influences infertility and subfertility in cattle.
Serial embryo transfer was previously used to classify heifers as high-fertile (HF), subfertile …

The bovine pre-implantation embryo secretes bioactive molecules from early development
stages, but effects on endometrial function are reported to start only after elongation. Here …

Gonadal sex differentiation proceeds by the interplay of various genes including the
transcription factors and secretory factors in a complex network. The sex-differentiating …