Submucosal glands contribute to airway surface liquid (ASL), a film that protects all airway
surfaces. Glandular mucus comprises electrolytes, water, the gel-forming mucin MUC5B …

The discovery of the Cystic fibrosis (CF) gene in 1989 has paved the way for incredible
progress in treating the disease such that the mean survival age of individuals living with CF …

Pilewski, Joseph M., and Raymond A. Frizzell. Role of CFTR in Airway Disease. Physiol.
Rev. 79, Suppl.: S215–S255, 1999.—Cystic fibrosis (CF) is caused by mutations in the gene …

The objective of this research was to examine the human sub-bronchial gland cell line, Calu-
3, and assess its potential as a metabolic and transport model to study drug delivery to the …

Serous cells are the predominant site of cystic fibrosis transmembrane conductance
regulator expression in the airways, and they make a significant contribution to the volume …

Most airway mucus is produced by submucosal glands in response to neural signals. Gland
mucus traps microbes, inhibits their replication, and clears them from the airways. In cystic …

Tight junctions (TJs) make a vital contribution to the barrier properties of the airway lining.
Opening of TJs, or their frank cleavage, is suspected as a pathophysiological event in the …

Cystic fibrosis (CF) is a pleiotropic disease, originating from mutations in the CF
transmembrane conductance regulator (CFTR). Lung injuries inflicted by recurring infection …

Recently, various types of cultured cells have been used to research the mechanisms of
transport and metabolism of drugs. Although many studies using cultured cell systems have …

The cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-dependent
protein kinase-and ATP-regulated chloride channel, the activity of which determines the rate …