ADAM17: a molecular switch to control inflammation and tissue regeneration
J Scheller, A Chalaris, C Garbers, S Rose-John - Trends in immunology, 2011 - cell.com
A disintegrin and metalloproteinase 17 (ADAM17), also known as tumor necrosis factor-α
converting enzyme (TACE), is a membrane-bound enzyme that cleaves cell surface …
converting enzyme (TACE), is a membrane-bound enzyme that cleaves cell surface …
ERK-mediated mechanochemical waves direct collective cell polarization
During collective migration of epithelial cells, the migration direction is aligned over a tissue-
scale expanse. Although the collective cell migration is known to be directed by mechanical …
scale expanse. Although the collective cell migration is known to be directed by mechanical …
Redox regulation of inflammatory processes is enzymatically controlled
I Lorenzen, L Mullen, S Bekeschus… - Oxidative medicine …, 2017 - Wiley Online Library
Redox regulation depends on the enzymatically controlled production and decay of redox
active molecules. NADPH oxidases, superoxide dismutases, nitric oxide synthases, and …
active molecules. NADPH oxidases, superoxide dismutases, nitric oxide synthases, and …
TGR5 is essential for bile acid-dependent cholangiocyte proliferation in vivo and in vitro
M Reich, K Deutschmann, A Sommerfeld, C Klindt… - Gut, 2016 - gut.bmj.com
Objective Cholestatic liver diseases in humans as well as bile acid (BA)-feeding and
common bile duct ligation (CBDL) in rodents trigger hyperplasia of cholangiocytes within the …
common bile duct ligation (CBDL) in rodents trigger hyperplasia of cholangiocytes within the …
Targeting Natural Killer Cells to Acute Myeloid Leukemia In Vitro with a CD16 × 33 Bispecific Killer Cell Engager and ADAM17 Inhibition
A Wiernik, B Foley, B Zhang, MR Verneris, E Warlick… - Clinical cancer …, 2013 - AACR
Purpose: The graft versus leukemia effect by natural killer (NK) cells prevents relapse
following hematopoietic stem cell transplantation. We determined whether a novel bispecific …
following hematopoietic stem cell transplantation. We determined whether a novel bispecific …
iRHOM2 is a critical pathogenic mediator of inflammatory arthritis
iRHOM2, encoded by the gene Rhbdf2, regulates the maturation of the TNF-α convertase
(TACE), which controls shedding of TNF-α and its biological activity in vivo. TACE is a …
(TACE), which controls shedding of TNF-α and its biological activity in vivo. TACE is a …
[HTML][HTML] ADAM17 substrate release in proximal tubule drives kidney fibrosis
Kidney fibrosis following kidney injury is an unresolved health problem and causes
significant morbidity and mortality worldwide. In a study into its molecular mechanism, we …
significant morbidity and mortality worldwide. In a study into its molecular mechanism, we …
Migration of growth factor-stimulated epithelial and endothelial cells depends on EGFR transactivation by ADAM17
T Maretzky, A Evers, W Zhou, SL Swendeman… - Nature …, 2011 - nature.com
The fibroblast growth factor receptor 2-IIIb (FGFR2b) and the vascular endothelial growth
factor receptor 2 (VEGFR2) are tyrosine kinases that can promote cell migration and …
factor receptor 2 (VEGFR2) are tyrosine kinases that can promote cell migration and …
Complexity of receptor tyrosine kinase signal processing
N Volinsky, BN Kholodenko - Cold Spring Harbor …, 2013 - cshperspectives.cshlp.org
Our knowledge of molecular mechanisms of receptor tyrosine kinase (RTK) signaling
advances with ever-increasing pace. Yet our understanding of how the spatiotemporal …
advances with ever-increasing pace. Yet our understanding of how the spatiotemporal …
Novel mechanistic insights into ectodomain shedding of EGFR Ligands Amphiregulin and TGF-α: impact on gastrointestinal cancers driven by secondary bile acids
Secondary bile acids (BA) such as deoxycholic acid (DCA) promote the development of
several gastrointestinal malignancies, but how they mediate this effect is unclear. In this …
several gastrointestinal malignancies, but how they mediate this effect is unclear. In this …