To maintain energy supply to the brain, a direct energy source called adenosine
triphosphate (ATP) is produced by oxidative phosphorylation and aerobic glycolysis of …

Abstract Sirtuin 1 (SIRT1), an NAD+-dependent deacetylase, has emerged as a key
regulator of cellular processes linked to ageing and neurodegeneration. SIRT1 modulates …

Since type 2 diabetes mellitus (T2DM) is a risk factor for Alzheimer's disease (AD) and both
have the same pathogenesis (eg, insulin resistance), drugs used to treat T2DM have been …

The discovery of new biomarkers that can distinguish Alzheimer's disease (AD) from mild
cognitive impairment (MCI) in the early stages will help to provide new diagnostic and …

Neurodegenerative disorders (NDDs) are a broad range of pathological conditions which
target the neurons, creating problems in movements and mental functions. The NDDs have …

Background Owing to the heterogeneity of Alzheimer's disease (AD), its pathogenic
mechanisms are yet to be fully elucidated. Evidence suggests an important role of …

Adipose tissue has recently been recognized as an important endocrine organ that plays a
crucial role in energy metabolism and in the immune response in many metabolic tissues …

Background The neuroprotective effects of Dehydroepiandrosterone (DHEA) and Hericium
erinaceus (H. erinaceus) mushroom extract against scopolamine-induced Alzheimer's …

Background Depression and diabetes mellitus (DM) are major chronic noncommunicable
diseases that impair one's mental and physical well-being and impose substantial burdens …

Amyloid beta (Aβ) plaques formation and impaired neurotransmission and neuronal
behaviors are primary hallmarks of Alzheimer's disease (AD) that are further associated with …