The light-sensitive outer segment organelle of the vertebrate photoreceptor cell is a modified
cilium filled with hundreds of flattened 'disc'membranes that provide vast light-absorbing …

Primary cilia are immotile organelles known for their roles in development and cell signaling.
Defects in primary cilia result in a range of disorders named ciliopathies. Because this …

Autophagy is controlled by AMPK and mTOR, both of which associate with ULK1 and control
the production of phosphatidylinositol 3-phosphate (PtdIns3P), a prerequisite for …

As signalling organelles, cilia regulate their G protein-coupled receptor content by
ectocytosis, a process requiring localised actin dynamics to alter membrane shape …

Primary cilia extending from mother centrioles are essential for vertebrate development and
homeostasis maintenance. Centriolar coiled-coil protein 110 (CP110) has been reported to …

Primary cilia are antenna-like subcellular structures to act as signaling platforms to regulate
many cellular processes and embryonic development. m1A RNA modification plays key …

Mutations in the Retinitis Pigmentosa GTPase Regulator (RPGR) cause X-linked RP
(XLRP), an untreatable, inherited retinal dystrophy that leads to premature blindness. RPGR …

Hyperactivation of Wnt/β-catenin signaling is one of the major causes of human colorectal
cancer (CRC). A hallmark of Wnt signaling is the nuclear accumulation of β-catenin …

Primary cilia, microtubule‐based protrusions present on the surface of most mammalian
cells, function as sensory organelles that monitor extracellular signals and transduce them …

Defects in cilia genes, which are critical for cilia formation and function, can cause
complicated ciliopathy syndromes involving multiple organs and tissues; however, the …