Dental, oral, and craniofacial (DOC) regenerative medicine aims to repair or regenerate
DOC tissues including teeth, dental pulp, periodontal tissues, salivary gland …

Salivary gland (SG) dysfunction impairs the life quality of many patients, such as patients
with radiation therapy for head and neck cancer and patients with Sjögren's syndrome …

Radiation therapy for head and neck cancers causes salivary gland dysfunction leading to
permanent xerostomia. Limited progress in the discovery of new therapeutic strategies is …

Salivary glands (SGs) play a vital role in maintaining oral health through the production and
release of saliva. Injury to SGs can lead to gland hypofunction and a decrease in saliva …

Synthetic matrices that are cytocompatible, cell adhesive, and cell responsive are needed
for the engineering of implantable, secretory salivary gland constructs to treat radiation …

Progress in the development of salivary gland regenerative strategies is limited by poor
maintenance of the secretory function of salivary gland cells (SGCs) in vitro. To reduce the …

Previous studies demonstrated that salivary gland morphogenesis and differentiation are
enhanced by modification of fibrin hydrogels chemically conjugated to Laminin-1 peptides …

Mimicking the complex architecture of salivary glands (SGs) outside their native niche is
challenging due their multicellular and highly branched organization. However, significant …

Sjögren's syndrome is a chronic inflammatory autoimmune disease characterized by
diminished secretory function of the exocrine glands. Although extensive investigation has …

Salivary gland biofabrication represents a promising avenue in regenerative medicine,
aiming to address the challenges of salivary gland dysfunction caused by various factors …