Executive summary Traumatic brain injury (TBI) has the highest incidence of all common
neurological disorders, and poses a substantial public health burden. TBI is increasingly …

Polygenic risk scores (PRSs) summarize the genetic predisposition of a complex human trait
or disease and may become a valuable tool for advancing precision medicine. However …

Objective The aim of this study was to further clarify clinical characteristics and predict
mortality risk among patients with viral pneumonia. Methods A total of 528 patients with viral …

The TRIPOD (Transparent Reporting of a multivariable prediction model for Individual
Prognosis Or Diagnosis) Statement includes a 22-item checklist, which aims to improve the …

Aims Systemic levels of trimethylamine N-oxide (TMAO), a pro-atherogenic and pro-
thrombotic metabolite produced from gut microbiota metabolism of dietary trimethylamine …

Clinical prediction models provide risk estimates for the presence of disease (diagnosis) or
an event in the future course of disease (prognosis) for individual patients. Although …

This article is the series of methodology of clinical prediction model construction (total 16
sections of this methodology series). The first section mainly introduces the concept, current …

Background Clinical prediction models are often not evaluated properly in specific settings
or updated, for instance, with information from new markers. These key steps are needed …

Prompt identification of acute coronary syndrome is a challenge in clinical practice. The 12-
lead electrocardiogram (ECG) is readily available during initial patient evaluation, but …

Background Polygenic risk scores (PRSs) can stratify populations into cardiovascular
disease (CVD) risk groups. We aimed to quantify the potential advantage of adding …